Pan-Influenza(AdaptVac)(Pan-Influenza(AdaptVac)) - 在研适应症：流感病毒感染_专利_临床

概要

基本信息

药物类型

预防性疫苗

别名-

靶点-

作用机制-

治疗领域

感染呼吸系统疾病

在研适应症

流感病毒感染

非在研适应症-

原研机构

Adaptvac ApS初创企业

在研机构

Adaptvac ApS初创企业

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Pan-Influenza(AdaptVac) 相关的临床结果

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100 项与 Pan-Influenza(AdaptVac) 相关的转化医学

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100 项与 Pan-Influenza(AdaptVac) 相关的专利（医药）

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1

项与 Pan-Influenza(AdaptVac) 相关的文献（医药）

Scientific Reports

Transcriptome analysis reveals a role of FOXO3 in antileukemia/lymphoma properties of panduratin A

Article

作者: Janpattanapichai, Jiranan ; Sirirak, Noppavut ; Phuagkhaopong, Suttinee ; Suknuntha, Kran ; Khemawoot, Phisit ; Vivithanaporn, Pornpun

Boesenbergia rotunda, commonly known as fingerroot, is a medicinal and culinary plant native to the Indochina Peninsula. We found that panduratin A (Pan-A), one of the compounds present in the rhizome extract of fingerroot, inhibited cell proliferation, induced apoptosis, and promoted cell cycle arrest at G0/G1 phase in multiple hematologic malignant cell lines including leukemia and lymphoma lines. Pan-A inhibited these activities in leukemia and lymphoma cells in a concentration-dependent manner. High-throughput transcriptome analysis indicated that Pan-A is involved in the cell cycle, cellular senescence, apoptosis, and multiple canonical signaling pathways in lymphoma cells. The Forkhead box O (FOXO) transcription factor family was identified as a potential target of Pan-A. Western blot showed elevated caspase 7 and cPARP/PARP in the B-cell lymphoma cells after treatment with Pan-A. The inhibitory effects were accompanied by stimulation of Akt signaling and phosphorylation of FOXO3. Immunohistochemistry of tissues from patients with B-cell lymphoma revealed detectable levels of FOXO3 protein specifically in neoplastic B cells. Overall, our results highlight FOXO3 as a player underlying antileukemia/lymphoma effects of Pan-A.

100 项与 Pan-Influenza(AdaptVac) 相关的药物交易

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