BACKGROUNDSurgeons face numerous choices in selecting sutures for skin closure, with potential adverse effects such as tissue tearing.OBJECTIVETo investigate the influence of needle design and suture gauge on tissue tearing during suturing procedures.MATERIALS AND METHODSThe authors tested the tear-through force in Newtons for 3 needle types and 3 suture gauges using an artificial skin model and a professional-grade tensiometer. Suture material was secured into the skin model, and force was applied to the suture at a constant rate, resulting in tearing. Force–displacement and force–time curves were generated. Evaluation included conventional cutting (PC-3), reverse cutting (PS-3), and taper point (BB) needles with a 5-0 polypropylene suture. In addition, nylon sutures with a reverse cutting needle (PS-2) were tested at 3 suture gauges (5-0, 4-0, 3-0).RESULTSThe mean tear-through forces for PC-3, PS-3, and BB were 3.26 N, 3.75 N, and 4.07 N, respectively. For the 5-0, 4-0, and 3-0 nylon sutures, the mean tear-through forces were 3.44 N, 3.81 N, and 4.04 N, respectively. Statistical analysis revealed a significant impact of suture gauge size (p < .001) and needle geometry (p < .001) on tear-through force.CONCLUSIONLarger suture diameter and taper needles minimize tissue tearing.

2024-09-01·Natural Product Research

Bioactive secondary metabolites isolated from the soft coral derived Penicillium sp. SCSIO 41038

Article

作者: Long, Jieyi ; Li, Yunqiu ; Yang, Bin ; Wang, Xueni ; Li, Huimin ; Liu, Yonghong ; She, Jianglian

Chemical investigation of the Penicillium sp. SCSIO 41038 led to the isolation and characterization of one new cyclopiazonic acid-type alkaloid, speradine I (1), and one new phloroglucinol derivative, speradine J (8), along with 13 known compounds. Their structures were determined on the basis of extensive spectroscopic analysis, and by a comparison with data from the literature. All the compounds were evaluated for their antitumor (22Rv1 and PC-3) and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro.

2024-09-01·Bioorganic Chemistry

Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers

Article

作者: Farag, Paula S ; Hemdan, Magdy M ; Hassaballah, Aya I ; Abd El-Mawgoud, Heba K ; Nemr, Mohamed T M ; AboulMagd, Asmaa M

Novel thieno[2,3-d]pyrimidine analogues were designed, synthesized and evaluated for anti-proliferative activity against HepG-2, PC-3 and MCF-7 cancer cell lines. In addition, WI-38 normal cell line was used to explore the safety of all the tested compounds. Compounds 2 (IC₅₀ = 4.29 µM HePG-2, 10.84 µM MCF-7), 6 (IC₅₀ = 14.86 μM HePG-2, 8.04 μM PC-3 and 12.90 μM MCF-7) and 17 (IC₅₀ = 9.98 μM HePG-2, 33.66 μM PC-3 and 14.62 μM MCF-7) were the most promising candidates on the tested cancer cells with high selective toxicity-sparing normal cells. A further mechanistic evaluation revealed promising kinase inhibitory activity, where compound 2 inhibited VEGFR-2 and AKT at IC₅₀ = 0.161 and 1.06 μM, respectively, Furthermore, derivative 6 inhibited VEGFR-2 and AKT at IC₅₀ = 0.487 and 0.364 μM, respectively, while compound 17 showed IC₅₀ = 0.164 and 0.452 μM, respectively. Moreover, compounds 2, 6 resulted in G1 phase cell cycle arrest while candidate 17 arrest cell cycle at G2/M phase. Similar to the apoptosis results, compound 17 showed the highest autophagic induction among the evaluated derivatives. Finally, docking studies were conducted to assess the binding patterns of these active derivatives. The results showed that the binding patterns inside the active sites of both the VEGFR-2 and AKT-1 (allosteric pocket) crystal structures were identical to the reference ligands.

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适应症	最高研发状态	国家/地区	公司	日期
哮喘	临床申请批准	中国	江苏长泰药业股份有限公司	2024-11-12
支气管扩张	临床申请批准	中国	江苏长泰药业股份有限公司	2024-11-12