UCPH-101(UCPH-101) - 药物靶点：EAAT1_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

EAAT1

作用机制

EAAT1 blockers(solute carrier family 1 member 3 blockers)

治疗领域-

在研适应症-

非在研适应症-

原研机构

University of Copenhagen

在研机构

University of Copenhagen

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C27H22N2O3

InChIKeyYBMGNDPBARCLFT-UHFFFAOYSA-N

CAS号1118460-77-7

关联

100 项与 UCPH-101 相关的临床结果

登录后查看更多信息

100 项与 UCPH-101 相关的转化医学

登录后查看更多信息

100 项与 UCPH-101 相关的专利（医药）

登录后查看更多信息

1

项与 UCPH-101 相关的文献（医药）

Communications Biology

EphrinB2 in excitatory neurons and astrocytes in the basolateral amygdala controls long-term fear memory formation

Article

作者: Farhat, Amira ; Lamprecht, Raphael ; Agarwal, Karishma

EphrinB2 regulates synaptic transmission and morphology however its role in memory formation is unknown. Here we show that deleting ephrinB2 from excitatory neurons in the basolateral amygdala (BLA) of male mice impairs long-term (LTM), but not short-term (STM), fear memory formation. Deleting ephrinB2 from astrocytes in the BLA impairs fear LTM but not STM. Removing ephrinB2 from astrocytes in the BLA reduces the level of the excitatory amino acid transporter 1 (EAAT1) in these cells. Inhibiting EAAT1 activity in the BLA during fear conditioning, by its specific inhibitor UCPH-101, impairs fear LTM showing that EAAT1 in the BLA is needed for fear LTM formation. The administration of ephrinB2 into the BLA during fear conditioning training enhances fear LTM. Moreover, ephrinB2 increases the ability of fear conditioning to activate cells in the BLA as detected by c-Fos labeling. EphrinB2 therefore determines the threshold for fear memory formation. In contrast to mature neurons, we show that ephrinB2 in neural stem cells (NSCs) is not needed for fear LTM. Our study shows that ephrinB2 in the BLA determines the strength of long-term memory consolidation.

100 项与 UCPH-101 相关的药物交易

登录后查看更多信息