HS is relatively common in the United States with a prevalence of 0.1-1.0%. 1 HS has a dramatic impact on quality of life, significantly more so than other chronic skin diseases, such as psoriasis or atopic dermatitis (AD). HS also has a large economic impact, due to frequent emergency department and inpatient care utilization, and re-hospitalization rates similar to congestive heart failure. Unfortunately, few treatment options are effective. There is only one currently FDA-approved treatment, adalimumab, but only 40- 60% respond to treatment and over 50% lose response within one year . The overarching goal of this pilot study is to investigate the central hypothesis that oral microbiota transplant therapy(MTT) alters the gut microbiome in patients with Hidradenitis Suppurativa (HS), influencing cutaneous microbiota via systemically absorbed gut-derived metabolites.

开始日期2023-10-01

申办/合作机构

University of Minnesota

NCT04105270 / Recruiting临床2期IIT

A Randomized Double Blind Phase II Trial of Restorative Microbiota Therapy (RMT) in Combination With Durvalumab (MEDI4736) and Chemotherapy in Untreated Patients With Advanced or Metastatic Adenocarcinoma Non-Small Cell Lung Cancer

This is a randomized, active-controlled, parallel-group, double-blind Phase II trial, of oral restorative microbiota therapy (RMT) or placebo combined with intravenous (IV) durvalumab (MEDI4736) plus chemotherapy in patients with treatment naïve advanced or metastatic adenocarcinoma non-small cell lung cancer (NSCLC)

开始日期2022-11-30

申办/合作机构

University of Minnesota

NCT05248191 / Active, not recruiting临床1期IIT

Fecal Microbiota Transplant for Postoperative Crohn's Disease

People with Crohn's disease often need surgery. The gut bacteria of people with Crohn's is associated with Crohn's disease coming back after surgery. Fecal microbiota transplant (FMT) after surgery might be a way to prevent Crohn's disease from coming back after surgery.
This study aims to determine if fecal microbiota transplant (FMT) taken by capsules results in the same amount of good bacteria in the guts as FMT by colonoscopy in people with Crohn's disease who have had surgery.
Participants will be randomized to get FMT by capsules or colonoscopy. Colonoscopy with biopsies 8-weeks after the FMT will be used to assess the good bacteria in the gut.

开始日期2022-04-20

申办/合作机构

University of Minnesota

100 项与 MCT-101 相关的临床结果

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100 项与 MCT-101 相关的转化医学

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100 项与 MCT-101 相关的专利（医药）

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100 项与 MCT-101 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
肺腺癌	临床2期	美国	University of Minnesota	2022-11-30
便秘	临床2期	美国	Finch Therapeutics Group, Inc.	2019-11-15
便秘	临床2期	美国	University of Minnesota	2019-11-15
便秘	临床2期	美国	Arizona State University	2019-11-15
腹泻	临床2期	美国	Finch Therapeutics Group, Inc.	2019-11-15
腹泻	临床2期	美国	University of Minnesota	2019-11-15
腹泻	临床2期	美国	Arizona State University	2019-11-15
急性髓性白血病	临床2期	美国	University of Minnesota	2019-09-09
急性髓性白血病	临床2期	美国	University of Minnesota Masonic Cancer Center	2019-09-09
造血干细胞移植	临床2期	美国	University of Minnesota Masonic Cancer Center	2019-09-09