R-71762(R-71762) - 药物靶点：Bacterial DNA gyrase x Top II_专利_临床

概要

基本信息

药物类型

小分子化药

别名

R-71762

靶点

Bacterial DNA gyrase x Top II

作用机制

Bacterial DNA gyrase 抑制剂(细菌DNA旋转酶抑制剂)、Top II抑制剂(拓扑异构酶II抑制剂)

治疗领域

免疫系统疾病感染泌尿生殖系统疾病

在研适应症-

非在研适应症

HIV感染

原研机构

Sankyo Co., Ltd. (Tokyo)

在研机构-

非在研机构

Sankyo Co., Ltd. (Tokyo)

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 R-71762 相关的临床结果

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100 项与 R-71762 相关的转化医学

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100 项与 R-71762 相关的专利（医药）

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1

项与 R-71762 相关的文献（医药）

1999-01-01·Chemotherapy4区 · 医学

A New Fluoroquinolone Derivative Exhibits Inhibitory Activity against Human Immunodeficiency Virus Type 1 Replication

4区 · 医学

Article

作者: Kashiwase, Hiroto ; Komai, Tomoaki ; Shimada, Kaoru ; Kimura, Tomio ; Ohmine, Toshinori ; Momota, Kenji ; Nishigaki, Takashi ; Kimura, Satoshi ; Furukawa, Hidehiko ; Katsube, Tetsushi

The inhibitory activity of several fluoroquinolone antibiotics against human immunodeficiency virus type 1 (HIV-1) replication was investigated. R-71762, (±) 9-fluoro-3-fluoromethyl-2,3-dihydro-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, protected MT-4 cells from HIV-1-induced cytopathic effects. Furthermore, the compound inhibited virus replication both in acutely and in chronically HIV-1-infected cells. On the other hand, ofloxacin, levofloxacin, ciprofloxacin, norfloxacin and enoxacin, that were previously reported to be protective against HIV-1-induced cytopathic effects, did not show any protective activity in our assay system. These results indicate that R-71762 is a novel inhibitor of HIV-1 replication and is effective even in HIV-1 chronically infected cells.

100 项与 R-71762 相关的药物交易

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