作者: Quintana, José Benito ; Alves, Nélson ; Coimbra, Ana M. ; Pinheiro, Marlene ; Herath, Lihini Athapaththu ; Ribeiro, Marta ; Rodil, Rosario ; Santos, Hugo G. ; Branco, Ricardo ; Montes, Rosa ; Martinez, Olga ; Barros, Susana ; Santos, Miguel M. ; Neuparth, Teresa ; Morais, Hugo

The nonsteroidal anti-inflammatory drug naproxen (NPX) is among the most consumed pharmaceuticals worldwide, being detected in surface waters within the ng to μg/L range. Considering the limited chronic ecotoxicity data available for NPX in aquatic ecosystems, the present study aimed at evaluating its impact in the model organism Danio rerio, following a full life-cycle exposure to environmentally relevant concentrations (0.1 to 5.0 μg/L). An integration of apical endpoints, i.e., survival, growth, and reproduction, with gonad histopathology and gene transcription (RNA-seq) was performed to provide additional insights into the mode of action (MoA) of NPX. NPX decreased zebrafish growth and reproduction and led to histopathological alterations in gonads at concentrations as low as 0.1 μg/L. At the molecular level, 0.7 μg/L of NPX led to a disruption in gonads transcription of genes involved in several biological processes associated with reproduction, mainly involving steroid hormone biosynthesis and epigenetic/epitranscriptomic machineries. Collectively, these results show that environmentally realistic concentrations of NPX affect zebrafish reproduction and associated signaling pathways, indicating that current hazard and risk assessment data for NPX underestimate the environmental risk of this pharmaceutical.

2024-11-01·ENVIRONMENTAL POLLUTION

The surface functional groups-driven fast and catalytic degradation of naproxen on sludge biochar enhanced by citric acid

Article

作者: Li, Shasha ; Shi, Yintao ; Deng, Huiyuan ; Zhang, Hao ; Xia, Dongsheng ; Li, Meng ; Jiao, Min

In this work, a sludge biochar (CA-SBC-300) with efficient activation of peroxymonosulfate (PMS) was prepared by citric acid modification. CA-SBC-300 achieved efficient degradation of naproxen (NPX) (95.5%) within 10 min by activating PMS. This system was highly resilient to common disruptive factors such as inorganic anions, humic acid (HA) and solution pH. The results of XPS and Raman showed that the content of oxygenated functional groups (OFGs) and the degree of defects on the sludge biochar increased after citric acid modification, which may be an important reason for the enhanced catalytic performance of SBC. In the CA-SBC-300/PMS system, ¹O₂ and O₂^•- made the main contributions to the degradation of NPX. XPS analysis and DFT calculations demonstrated that C=O/C-O and pyridine N on CA-SBC-300 were the crucial active sites for PMS activation. According to the results of UPLC-MS analysis, three possible pathways for NPX degradation were inferred. This study provided a feasible strategy for sludge resource utilization combined with efficient catalytic degradation of toxic organic contaminants in wastewater.

2024-11-01·ECOTOXICOLOGY

Response of crop seed germination and primary root elongation to a binary mixture of diclofenac and naproxen

Article

作者: Kummerová, Marie ; Zezulka, Štěpán ; Babula, Petr

Non-steroidal anti-inflammatory drugs, diclofenac (DCF) and naproxen (NPX), represent a group of environmental contaminants often detected in various water and soil samples. This work aimed to assess possible phytotoxic effects of DCF and NPX in concentrations 0.1, 1 and 10 mg/L, both individually and in binary mixtures, on the seed germination and primary root elongation of crops, monocots Allium porrum and Zea mays, and dicots Lactuca sativa and Pisum sativum. Results proved that the seed germination was affected by neither individual drugs nor their mixture. The response of primary root length in monocot and dicot species to the same treatment was different. The Inhibition index (%) comparing the root length of drug-treated plants to controls proved to be approximately 10% inhibition in the case of dicots lettuce and pea, and nearly 20% inhibition in monocot leek, but almost 20% stimulation in monocot maize. Assessment of the binary mixture effect confirmed neither synergistic nor antagonistic interaction of DCF and NPX on early plant development in the applied concentration range.

100 项与 Npx-Au 相关的药物交易

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