Efficient activation of peroxymonosulfate by N-doped waste herb senna obtusifolia biochar for degrading NPX: Synergistic effect of carbonyl and nitrogen sites

Article

作者: Shi, Yintao ; Zhang, Hao ; Deng, Huiyuan ; Xia, Dongsheng ; Zhang, Yaqi ; Li, Meng

In this work, waste herb senna obtusifolia was utilized as the biochar precursor, and a N-doped biochar (NSOBC-6) was prepared to activate peroxymonosulfate (PMS) for degrading Naproxen (NPX). NSOBC-6 exhibited superior catalytic performance in activating PMS, which could degrade NPX completely within 60 min. The NSOBC-6/PMS system also had good reusability and effectiveness under a wide range of pH values and high salinity conditions. The significant contribution of singlet oxygen (¹O₂) and superoxide radicals (O₂^•-) in NPX degradation was revealed. The results of XPS and DFT calculations indicated C=O, pyridinic-N and graphitic-N participated as catalytic sites in the degradation of NPX. The differences in electron density and the E_LUMO-E_HOMO (ΔE_LUMO-HOMO) gap were induced by N doping, enhancing the PMS activation capacity of NSOBC-6. This work presented a strategy to convert waste herbal into functional biochar materials, which was of great significance for the development of green and efficient catalysts.

2024-11-05·Environmental Science & Technology

Are Environmental Levels of Nonsteroidal Anti-Inflammatory Drugs a Reason for Concern? Chronic Life-Cycle Effects of Naproxen in Zebrafish

Article

作者: Barros, Susana ; Santos, Miguel M. ; Herath, Lihini Athapaththu ; Martinez, Olga ; Pinheiro, Marlene ; Santos, Hugo G. ; Alves, Nélson ; Coimbra, Ana M. ; Rodil, Rosario ; Quintana, José Benito ; Neuparth, Teresa ; Ribeiro, Marta ; Montes, Rosa ; Morais, Hugo ; Branco, Ricardo

The nonsteroidal anti-inflammatory drug naproxen (NPX) is among the most consumed pharmaceuticals worldwide, being detected in surface waters within the ng to μg/L range. Considering the limited chronic ecotoxicity data available for NPX in aquatic ecosystems, the present study aimed at evaluating its impact in the model organism Danio rerio, following a full life-cycle exposure to environmentally relevant concentrations (0.1 to 5.0 μg/L). An integration of apical endpoints, i.e., survival, growth, and reproduction, with gonad histopathology and gene transcription (RNA-seq) was performed to provide additional insights into the mode of action (MoA) of NPX. NPX decreased zebrafish growth and reproduction and led to histopathological alterations in gonads at concentrations as low as 0.1 μg/L. At the molecular level, 0.7 μg/L of NPX led to a disruption in gonads transcription of genes involved in several biological processes associated with reproduction, mainly involving steroid hormone biosynthesis and epigenetic/epitranscriptomic machineries. Collectively, these results show that environmentally realistic concentrations of NPX affect zebrafish reproduction and associated signaling pathways, indicating that current hazard and risk assessment data for NPX underestimate the environmental risk of this pharmaceutical.

2024-11-01·Ecotoxicology

Response of crop seed germination and primary root elongation to a binary mixture of diclofenac and naproxen

Article

作者: Kummerová, Marie ; Babula, Petr ; Zezulka, Štěpán

Non-steroidal anti-inflammatory drugs, diclofenac (DCF) and naproxen (NPX), represent a group of environmental contaminants often detected in various water and soil samples. This work aimed to assess possible phytotoxic effects of DCF and NPX in concentrations 0.1, 1 and 10 mg/L, both individually and in binary mixtures, on the seed germination and primary root elongation of crops, monocots Allium porrum and Zea mays, and dicots Lactuca sativa and Pisum sativum. Results proved that the seed germination was affected by neither individual drugs nor their mixture. The response of primary root length in monocot and dicot species to the same treatment was different. The Inhibition index (%) comparing the root length of drug-treated plants to controls proved to be approximately 10% inhibition in the case of dicots lettuce and pea, and nearly 20% inhibition in monocot leek, but almost 20% stimulation in monocot maize. Assessment of the binary mixture effect confirmed neither synergistic nor antagonistic interaction of DCF and NPX on early plant development in the applied concentration range.

100 项与 Npx-Au 相关的药物交易

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