Chiral alcs. are not only important building blocks of various bioactive natural compounds and pharmaceuticals, but can serve as synthetic precursors for other valuable organic chems., thus the synthesis of these products is of great importance.Bio-catalysis represents one effective way to obtain these mols., however, the weak stability and high cost of enzymes often hinder its broad application.In this work, we designed a biol. nanoreactor by embedding alc. dehydrogenase (ADH) and glucose dehydrogenase (GDH) in metal-organic-framework ZIF-8.The biocatalyst ADH&GDH@ZIF-8 could be applied to the asym. reduction of a series of ketones to give chiral alcs. in high yields (up to 99 %) and with excellent enantioselectivities (>99 %).In addition, the heterogeneous biocatalyst could be recycled and reused at least four times with slight activity decline.Moreover, E. coli containing ADH and GDH was immobilized by ZIF-8 to form biocatalyst E. coli@ZIF-8, which also exhibits good catalytic behaviors.Finally, the chiral alcs. are further converted to marketed drugs (R)-Fendiline, (S)-Rivastigmine and NPS R-568 resp.