Observational, Post-marketing Renal Safety Surveillance Registry in Subjects With Chronic Hepatitis B (HBV) Infection With Decompensated Liver Disease Receiving Nucleotide/Side Therapy

This registry will remain open for approximately 5 years (4 years of enrollment + 1 year of follow up). Subjects will be followed until Orthotopic Liver Transplant (OLT), resolution of liver decompensation, death, or conclusion of the registry.

开始日期2012-04-26

申办/合作机构

Gilead Sciences, Inc.

100 项与 Anti-HBV therapy(Apeloa) 相关的临床结果

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100 项与 Anti-HBV therapy(Apeloa) 相关的转化医学

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100 项与 Anti-HBV therapy(Apeloa) 相关的专利（医药）

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项与 Anti-HBV therapy(Apeloa) 相关的文献（医药）

2024-11-01·Current Opinion in HIV and AIDS

Hepatitis co-infection in paediatric HIV: progressing treatment and prevention

Article

作者: Rubino, Chiara ; Stinco, Mariangela ; Indolfi, Giuseppe

Purpose of reviewTo analyse the main evidence and recommendations for the management of hepatitis co-infection in children living with HIV.Recent findingsWe analysed available data pertaining to the natural history of liver disease and treatment of co-infected children.SummaryViral hepatitis co-infection in people living with HIV (PLHIV) is a global problem owing to the shared routes of transmission, particularly in areas of high endemicity for the three viruses. Viral hepatitis co-infection can accelerate liver disease progression and increase morbidity and mortality, even in patients on suppressive antiretroviral treatment (ART). Viral hepatitis should be routinely screened in PLHIV and, once diagnosed with viral hepatitis, PLHIV should be closely monitored for liver disease progression and complications. Children living with HIV-HBV co-infection should be treated with ART containing agents which are active against both viruses. Children living with HIV-HCV co-infection should receive directly acting antivirals (DAA) to eradicate HCV infection. Prevention measures to reduce vertical and horizontal transmission of HBV and HCV (anti-HBV vaccination and immunoglobulins, anti-HBV treatment in pregnancy, anti-HCV DAAs in people of childbearing age, avoiding blood contact, sexual barrier precautions) should be adopted and encouraged, particularly in high endemicity countries.

2024-09-01·Archives of Industrial Hygiene and Toxicology

Factors predicting the level of vaccine protection against hepatitis B virus infection among physicians and nurses in Šabac, Serbia

Article

作者: Maletić, Jelena Stojčević ; Vasić, Slobodanka Bogdanović ; Stevanović, Goran ; Milutinović, Dragana ; Svitlica, Branislava Brestovački ; Ružić, Maja ; Aranđelović, Branimirka ; Savić, Nikola

AbstractAs healthcare workers run a high and constant occupational risk of hepatitis B virus (HBV) infection through exposure to biological material, vaccination is mandatory as well as the monitoring of antibody levels one to two months after complete immunisation. The aim of this descriptive cross-sectional study was to determine HBV vaccine coverage of 200 primary and secondary healthcare workers (100 each) from Šabac, Serbia and their blood anti-HBs titre. We also wanted to identify factors that could predict the titre. Anti-HBV vaccination covered all participants, of whom 89.5 % were fully vaccinated, and 85 % had a protective antibody titre. We found a statistically significant association between antibody titre and the number of received vaccine doses, chronic jaundice, autoimmune disease, and cancer in our participants. The fact that 15 % did not achieve the protective antibody titre confirms the necessity of its control after immunisation, which is not routinely carried out in most countries, Serbia included. It is, therefore, necessary to develop a detailed strategy for monitoring vaccination and serological status of healthcare workers in order to improve their safety at work. An important role should also be given to continuous education of healthcare workers from the beginning of schooling to the end of their professional career.

2024-05-24·Advances in Virology

Evaluation of Immune Characteristics and Factors Associated with Immune Response following Hepatitis B Vaccination among Ghanaian Adolescents

Article

作者: Amoani, Benjamin ; Krampah Aidoo, Ebenezer ; Boakye, Godwin ; Opoku, Stephen ; Simon Olympio Mensah, Oscar ; Asamoah Sakyi, Samuel ; Badu Gyapong, Joseph ; Koffie, Simon ; Effah, Alfred ; Amadu Ngala, Robert ; Arddey, Isaac

Background. WHO recommends HBV-negative babies in high-prevalence (8%) countries receive anti-HBV vaccination. Ghana initiated mass immunization in 2002, but concerns remain about vaccine effectiveness and long-term protection. We evaluated immune characteristics and factors following hepatitis B vaccination among Ghanaian adolescents who received HBV vaccines. Methods. In this longitudinal cross-sectional study, 74 participants were enrolled from the Kumasi Metropolis, Ghana. Sociodemographic and lifestyle characteristics of participants were obtained using a questionnaire. Blood samples were obtained before and after booster administration for anti-HBsAg, IL-6, and IL-10 estimations using ELISA kit (Shanghai Chemical Ltd., China). Anti-HBsAg titers ≥10 mIU/ml were considered protective. Statistical analyses were done using SPSS version 26.0 and R programming language, p<0.05 was considered statistically significant. Results. We found 100% seroconversion rate, with 25.7% seroprotection rate (anti-HBsAg >10 mIU/ml). Gender (p=0.009), age (p=0.001), and exercising (p=0.044) were significantly associated with seroprotection. Following booster administration, 59.4% were hyporesponders (10 ≤ anti-HBsAg titre ≤99 mIU/ml) whilst 40.6% were good responders (anti-HBsAg titre ≥100 mIU/ml). Exercise (p=0.034) was significantly associated with immune response after booster administration. Moreover, we reported significant positive correlation between cytokines [IL-6 (r = 0.817, p<0.001) and IL-10 (r = 0.928, p<0.001)] and anti-HBsAg titre. Conclusion. Approximately two thirds of adolescents vaccinated at birth lack protective levels of antibodies against hepatitis B virus. Booster vaccines could aid in mounting protective levels of anti-HBsAg. Physical exercise was negatively associated with immune response to hepatitis B vaccinations.

100 项与 Anti-HBV therapy(Apeloa) 相关的药物交易

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