Resorstatin(Resorstatin) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Kirin

在研机构-

非在研机构

Kirin

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C17H28O2

InChIKeyGAZJVWPMPITOLB-UHFFFAOYSA-N

CAS号139552-96-8

关联

100 项与 Resorstatin 相关的临床结果

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100 项与 Resorstatin 相关的转化医学

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100 项与 Resorstatin 相关的专利（医药）

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2

项与 Resorstatin 相关的文献（医药）

2006-04-01·Journal of Natural Products2区 · 生物学

Antimicrobial Dialkylresorcinols from Pseudomonas sp. Ki19

2区 · 生物学

Article

作者: Broberg, Anders ; Pohanka, Anton ; Levenfors, Jolanta

Four dialkylresorcinols (1-4) were isolated from a liquid culture of Pseudomonas sp. Ki19. Compounds 1 and 2, 2-butyl-5-propylresorcinol and 2-hexyl-5-methylresorcinol, respectively, have not previously been isolated from biological sources, whereas 3 and 4, 2-hexyl-5-propylresorcinol (DB-2073) and 2-hexyl-5-pentylresorcinol (resorstatin), both have been found in biological systems. The compounds inhibited Staphyllococcus aureus at concentrations < or = 10 microg/mL as well as the fungi Aspergillus fumigatus and Fusarium culmorum at 50 microg/mL. The formation of possible antimicrobial quinone oxidation products was investigated under bioassay conditions, and they were not found to be responsible for the main antimicrobial activity.

1993-01-01·The Journal of Antibiotics4区 · 医学

Studies on free radical scavenging substances from microorganisms. III. Isolation and structural elucidation of a novel free radical scavenger, resorstatin.

4区 · 医学

Article

作者: Mochizuki, Junichiro ; Matsuoka, Michiko ; Shindo, Kazutoshi ; Kato, Shinichiro ; Kawai, Hiroyuki

An alkylresorcinol-type compound named resorstatin was isolated from the culture of Pseudomonas sp. DC165.Resorstatin is structurally related to DB-2073 previously reported by N. Kanda et al. (1975).Resorstatin has shown a strong inhibitory activity against lipid peroxidation induced by free radicals in rat brain homogenate.In this paper, the authors report the isolation, structural elucidation and biol. activity of this compound

100 项与 Resorstatin 相关的药物交易

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