This study evaluates the efficacy of clinical nutrition to treat lung neoplasms and breast carcinoma.We estimate there will be 480 patients accepted.120 patients will receive GLSE compound,120 patients will recrive Maitake mushroom extract compound,120 patients will recrive Rinseng compound,and 120 patients will be as blank countrol group.Efficacy Study of Clinical Nutrition to Treat Lung Neoplasms And Breast Carcinoma

开始日期2015-11-01

申办/合作机构

中国人民解放军总医院

NCT01375114 / Active, not recruiting临床2期IIT

The Effects of Ginseng on Cancer-Related Fatigue

The goal of this clinical research study is to learn if panax ginseng (commonly called ginseng) can help to control fatigue and other symptoms such as depression, anxiety, and mood changes in patients with cancer. The safety of ginseng will also be studied.

开始日期2011-10-01

申办/合作机构

The University of Texas MD Anderson Cancer Center

[+1]

NCT00103012 / Completed临床4期IIT

The Influence of Concurrent Administration of Echinacea Purpurea, Ginkgo Biloba, or Panax Ginseng on the Steady State Pharmacokinetic Profile of Lopinavir/Ritonavir in Healthy Volunteers

This study will examine the interaction of the HIV combination medication lopinavir/ritonavir with the herbal products echinacea, ginseng, and ginkgo biloba. Patients with HIV infection often take herbal products and dietary supplements in addition to their doctor-prescribed medicines to treat the disease, lessen the side effects of anti-viral drugs, and improve their overall well being. Alternative medicines such as these may, however, interfere with the elimination of lopinavir/ritonavir from the body, causing either higher or lower blood levels of these drugs than would be expected. This study will assess in healthy subjects any potential harms of taking echinacea, ginseng, or ginkgo biloba together with lopinavir/ritonavir.
Healthy normal volunteers between 18 and 50 years of age may be eligible for this study. Candidates are screened with a history, physical examination, and blood tests, including an HIV test and a pregnancy test for women. Pregnant women are excluded from the study. Participants come to the NIH Clinical Center after fasting overnight for the following procedures:
Visits 1 and 2: A catheter (plastic tube) is placed in an arm vein to collect blood samples. After the first sample is drawn, the subject takes 8 mg of midazolam syrup and two fexofenadine tablets. Midazolam is a sedative, and fexofenadine (Allegra) is a medicine used to treat allergies. Subjects are given breakfast an hour after taking the drugs. Blood samples are collected at 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8 and 24 hours after taking the drugs to measure blood levels of fexofenadine. An extra sample is collected at the 4-hour mark to measure the midazolam level. The catheter is removed after the 8-hour blood draw and subjects are dismissed home. They return the following morning (visit 2) for the 24-hour blood draw.
Visit 3: From 7 to 28 days after visit 1, subjects begin taking lopinavir/ritonavir capsules twice a day by mouth for a total of 29.5 days. On day 15 they return to the clinic for lopinavir/ritonavir blood levels as were done for fexofenadine, except that samples are collected once before breakfast and then at 0.5, 1, 2, 3, 4, 6, 8 and 12 hours after the lopinavir/ritonavir dose. An extra sample is collected for routine tests. The catheter is removed after the 12-hour draw and the subject is dismissed home.
The next morning, subjects begin taking one of the following: echinacea 500 mg 3 times a day; ginkgo biloba 120 mg twice a day; or ginseng 500 mg 3 times a day for 28 days.
Visit 4: On the last day of taking lopinavir/ritonavir, subjects return to the clinic again for blood level measurements of these drugs as on visit 3, except that the catheter is removed and the subject dismissed home after the 8-hour blood draw.
Visits 5 and 6: On the last day of taking the herbal supplement, subjects return to the clinic for repeat measurement of fexofenadine and midazolam levels, as described in visits 1 and 2. At the final visit (visit 6) an additional blood sample is collected for repeat laboratory testing.
...

开始日期2005-01-01

申办/合作机构

National Institutes of Health Clinical Center

100 项与人参提取物相关的临床结果

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100 项与人参提取物相关的转化医学

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100 项与人参提取物相关的专利（医药）

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项与人参提取物相关的文献（医药）

2024-12-01·Molecular biology reports

Physiological roles of propolis and red ginseng nanoplatforms in alleviating dexamethasone-induced male reproductive challenges in a rat model

Article

作者: Aziz, Rabie L Abdel ; Farghali, Ahmed A ; Kamel, Shaimaa ; Ibrahim, Marwa A ; Abdel-Wahab, Ahmed ; Abdel-Razik, Abdel-Razik H ; Saleh, Romaissaa ; El-Ela, Fatma I Abo ; Mahmoud, Rehab ; Nabil, Taghred M

Abstract:

Background:

Red ginseng and propolis are well-known antioxidants that have been related to a reduction in oxidative stress.

Objective:

This study evaluated the efficiency of red ginseng and propolis, either in powder or as nano-forms against dexamethasone—induced testicular oxidative challenges in adult male albino rats.

Methods:

Forty rats were divided into 8 equal groups including control negative group that was given vehicle (DMSO), control positive group that was administered dexamethasone in addition to the nano-propolis, nano-ginseng, nano-propolis + dexamethasone, nano ginseng+dexamethasone, propolis+dexamethasone and ginseng + dexamethasone groups. Serum, semen and tissue samples were obtained.

Results:

Lower testosterone levels, higher levels of MDA, and lower levels of total antioxidant capacity in serum, as well as impaired semen quality and a disturbed histopathological picture of both the testis and seminal glands, were all observed as significant negative effects of dexamethasone. These findings were confirmed by lower gene expression profiles of CYP11A1, StAR, HSD-3b, Nrf-2 and ACTB-3b in testicular and seminal gland tissues. The most powerful anti-dexamethasone effects were obtained with either propolis in nanoform or conventional ginseng.

Conclusion:

Propolis nano-formulation and ginseng in conventional form could be considered excellent candidates to ameliorate the oxidative stress provoked by dexamethasone, however, neither nano-ginseng nor conventional propolis showed such effects.

2024-04-01·Journal of ethnopharmacology

Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells

Article

作者: Zhang, Duoduo ; Li, Weizu ; Sun, Ran ; Kong, Liangliang ; Zhou, Huimin ; Xu, Hanyang ; Li, Weiping ; Ji, Pengmin ; Su, Yong ; Liu, Yan

ETHNOPHARMACOLOGICAL RELEVANCE:

Ginseng (Panax ginseng C. A. Meyer) is a precious traditional Chinese medicine with multiple pharmacological effects. Ginsenoside Rg1 is a main active ingredient extracted from ginseng, which is known for its age-delaying and antioxidant effects. Increasing evidence indicates that Rg1 exhibits anti-inflammatory properties in numerous diseases and may ameliorate oxidative damage and inflammation in many chronic liver diseases.

AIM OF THE STUDY:

Chronic inflammatory injury in liver cells is an important pathological basis of many liver diseases. However, its mechanism remains unclear and therapeutic strategies to prevent its development need to be further explored. Thus, our study is to delve the protective effect and mechanism of Rg1 against chronic hepatic inflammatory injuries induced by lipopolysaccharide (LPS).

MATERIALS AND METHODS:

The chronic liver damage model in mice was build up by injecting intraperitoneally with LPS (200 μg/kg) for 21 days. Serum liver function indicators and levels of IL-1β, IL-6 and TNF-α were examined by using corresponding Kits. Hematoxylin and Eosin (H&E), Periodic acid-Schiff (PAS), and Masson stains were utilized to visualize hepatic histopathological damage, glycogen deposition, and liver fibrosis. The nuclear import of p-Nrf2 and the generation of Col4 in the liver were detected by IF, while IHC was employed to detect the expressions of NLRP3 and AIM2 in the hepatic. The Western blot and q-PCR were used to survey the expressions of proteins and mRNAs of fibrosis and apoptosis, and the expressions of Keap1, p-Nrf2 and NLRP3, NLRP1, AIM2 inflammasome-related proteins in mouse liver. The cell viability of human hepatocellular carcinoma cells (HepG2) was detected by Cell Counting Kit-8 to select the action concentration of LPS, and intracellular ROS generation was detected using a kit. The expressions of Nuclear Nrf2, HO-1, NQO1 and NLRP3, NLRP1, and AIM2 inflammasome-related proteins in HepG2 cells were detected by Western blot. Finally, the feasibility of the molecular interlinking between Rg1 and Nrf2 was demonstrated by molecular docking.

RESULTS:

Rg1 treatment for 21 days decreased the levels of ALT, AST, and inflammatory factors of serum IL-1β, IL-6 and TNF-α in mice induced by LPS. Pathological results indicated that Rg1 treatment obviously alleviated hepatocellular injury and apoptosis, inflammatory cell infiltration and liver fibrosis in LPS stimulated mice. Rg1 promoted Keap1 degradation and enhanced the expressions of p-Nrf2, HO-1 and decreased the levels of NLRP1, NLRP3, AIM2, cleaved caspase-1, IL-1β and IL-6 in livers caused by LPS. Furthermore, Rg1 effectively suppressed the rise of ROS in HepG2 cells induced by LPS, whereas inhibition of Nrf2 reversed the role of Rg1 in reducing the production of ROS and NLRP3, NLRP1, and AIM2 expressions in LPS-stimulated HepG2 cells. Finally, the molecular docking illustrated that Rg1 exhibits a strong affinity towards Nrf2.

CONCLUSION:

The findings indicate that Rg1 significantly ameliorates chronic liver damage and fibrosis induced by LPS. The mechanism may be mediated through promoting the dissociation of Nrf2 from Keap1 and then activating Nrf2 signaling and further inhibiting NLRP3, NLRP1, and AIM2 inflammasomes in liver cells.

2024-02-01·Inflammopharmacology

Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19

Review

作者: Yu, Qin ; Zhao, Fangyi ; Zhao, Jiayu ; Chen, Hongyu ; Cui, Ranji ; Zhang, Kai ; Ruan, Mengyu ; Li, Bingjin ; Zhang, Tianqi ; Lv, Qianyu

Abstract:

Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients has increased, some of those infected with SARS-CoV-2 have developed a variety of psychiatric symptoms, including depression, cognitive impairment, and fatigue. A distinct storm of inflammatory factors that contribute to the initial disease but also a persistent post-acute phase syndrome has been reported in patients with COVID-19. Neuropsychological symptoms including depression, cognitive impairment, and fatigue are closely related to circulating and local (brain) inflammatory factors. Natural products are currently being examined for their ability to treat numerous complications caused by COVID-19. Among them, ginseng has anti-inflammatory, immune system stimulating, neuroendocrine modulating, and other effects, which may help improve psychiatric symptoms. This review summarizes the basic mechanisms of COVID-19 pneumonia, psychiatric symptoms following coronavirus infections, effects of ginseng on depression, restlessness, and other psychiatric symptoms associated with post-COVID syn-dromes, as well as possible mechanisms underlying these effects.

项与人参提取物相关的新闻（医药）

2023-12-21

·PRNewswire

Greenfilled's Energy Supplement Is a Synergistic Replacement for Energy Drinks

The Formula Brings Phytoplankton, Ashwagandha, Panax Ginseng, and Vitamin C Together to Deliver a Supercharged Dose of Natural Stimulation FORT LAUDERDALE, Fla., Dec. 21, 2023 /PRNewswire/ -- The energy drink industry dominates the stimulant market. But energy drinks have some nasty side effects. Greenfilled's Energy supplement provides a calculated dose of clean, green ingredients that help the body stay energized without the energy crashes and exhaustion that are all too common with traditional energy drinks. In fact, unlike energy drinks, the innovative supplement actually improves health all the way down to a cellular level. The energy drink industry is wildly popular. According to Grand View Research, the market stood at $86.35 billion and growing in 2021. Statista puts the 2021 revenue figure higher at approximately $159 billion, which comes out to a per-person spend of around $21 annually. The research site adds that the market is expected to expand to over $233 billion by 2027 — less than half a decade from now. The big attraction of energy drinks comes from the high degree of caffeine, sugar, taurine, and other stimulating ingredients present in most formulas. These deliver a fast and intense energy boost — but they come at a cost. The United States Marine Corps outlines several common symptoms of excessive energy drink use, including dehydration, sleeplessness, nausea, irritability, and anxiety. This can end with consumers not just in pain but hospitalized, as well. The team at Greenfilled understands the need for dependable, ongoing energy to meet the endless demands of 21st-century life. "The need for energy is very real," says Greenfilled COO Enrique Castaño. "That's why we came up with a solution that helps fill that gap without using harmful or unnatural ingredients." Greenfilled's Energy supplement is a clean, green source of nutrients that brings together four natural alternatives to energy drink ingredients. Each of these is pivotal to maintaining energy on a basic level and includes: Phytoplankton provides natural energy on a cellular level. Ashwagandha is known for its rejuvenating and restorative properties. Panax Ginseng promotes relaxation, lowers blood sugar, and, critically, boosts energy levels. Vitamin C is also known for helping battle fatigue, along with its immunity-boosting properties. Together, this quartet of natural ingredients combine in the Energy supplement formula. This creates a maximum benefit that Greenfilled customers can tap into by simply taking one capsule a day with a glass of water. It is an accessible, sustainable, and healthy way to keep the body fueled and capable of handling everything that life sends at it. About Greenfilled Greenfilled is a health and wellness brand founded by the Spain-based Marine Biotech Company Fitoplancton Marino. The parent company's mission is to research, develop, and supply microalgae-based products that improve health and quality of life. Greenfilled is a manifestation of this mission, with the brand's supplements utilizing sustainably farmed, high-quality phytoplankton that delivers robust levels of the antioxidant enzyme superoxide dismutase (SOD) through its flagship ingredient TetraSOD®. Greenfilled products help with many health concerns, including rest, recovery, energy levels, and cognitive clarity. Learn more at greenfilled.com. Media Contact: Enrique Castaño Sales & Business Development Director Fitoplancton Marino, S.L Phone + 34 620003888 [email protected] SOURCE Greenfilled

2023-12-21

·PRNewswire

Guarding Against SAD With Greenfilled Supplements

Seasonal Affective Disorder Is a Common Struggle for Many Individuals. Greenfilled's Memory Supplement Is a Natural Support for Cognitive Well-Being. FORT LAUDERDALE, Fla., Dec. 21, 2023 /PRNewswire/ -- Greenfilled's Memory supplement features a combination of natural ingredients, including phytoplankton, Ginkgo Biloba, Panax Ginseng, and Bacopa Monnieri. Together, these provide a synergistic range of benefits that help support overall cognitive well-being. This can help with things like memory and critical thinking. Fueling the body with basic nutrition required for cognitive health can also have the added benefit of helping it naturally ward off seasonal depression. "When you encourage proper neuronal functioning and overall cognitive activity, it can have a huge impact on how you handle things like anxiety and depression," explains Greenfilled COO Enrique Castaño. "Our goal is to help the body function as healthy as possible, including the brain, so that it can stay healthy and balanced. This doesn't mean our Memory formula is a direct solution for anxiety and depression, but it absolutely provides a baseline of cognitive health that is crucial in the ongoing fight for mental health and clarity." Approximately 5% of U.S. adults experience SAD for a significant portion of the year. Usually, this is connected to the fall and winter months, leading to its nickname of the "winter blues." SAD is linked to biochemical imbalances in the brain resulting from shorter days. There are many solutions on the market for SAD. Mayo Clinic reports that those with the condition can use light therapy, psychotherapy, and stronger medications to address the issue. As a green, clean alternative, Greenfilled's Memory supplement provides key cognitive ingredients that support healthy brain function. Ginkgo Biloba, for example, has been known as an effective treatment for depression. Bacopa Monnieri has a similar track record, and Panax Ginseng has also been proven to be effective as a mood regulator. Even Greenfilled's flagship ingredient, TetraSOD®, helps the mind on a cellular level. It is a critical compound of concentrated superoxide dismutase, which functions as the first essential enzyme in the antioxidant pathway. It is a powerful tool in reducing oxidative stress and is a critical compound found in every healthy cell. SAD is a common struggle for millions of individuals throughout the fall and winter months. As they wait for days to get longer again, those managing SAD can use a daily dose of Greenfilled's Memory supplement to keep their mind strong and their cognition sharp as they seek to minimize and manage anxiety and depression on an annual basis. About Greenfilled Greenfilled is a health and wellness brand founded by the Spain-based Marine Biotech Company Fitoplancton Marino. The parent company's mission is to research, develop, and supply microalgae-based products that improve health and quality of life. Greenfilled is a manifestation of this mission, with the brand's supplements utilizing sustainably farmed, high-quality phytoplankton that delivers robust levels of the antioxidant enzyme superoxide dismutase (SOD) through its flagship ingredient TetraSOD®. Greenfilled products help with many health concerns, including rest, recovery, energy levels, and cognitive clarity. Learn more at greenfilled.com. Media Contact: Enrique Castaño Sales & Business Development Director Fitoplancton Marino, S.L Phone + 34 620003888 [email protected] SOURCE Greenfilled

2023-06-30

·PRNewswire

Greenfilled Is Combatting the Effects of Age with Phytoplankton

The Superoxide Dismutase Enzyme Offers a Simple, Cost-Effective Solution to Healthy Aging and Addressing Oxidative Stress FORT LAUDERDALE, Fla., June 30, 2023 /PRNewswire/ -- Aging is a natural process. Once an individual reaches adulthood, it's only a matter of time before their skin, hair, eyes, bones, organs, and other principal body parts begin to suffer from the wear and tear of everyday use. While there is no way to completely stop aging, Greenfilled has invested in creating a range of dietary supplements that facilitate a healthy aging process. Greenfilled is an earth-conscious health brand that is committed to ethically supporting human health. Each of the Spanish-based brand's products utilizes different herbal ingredients, Ginkgo Biloba for memory, Panax Ginseng for fatigue, and so on. However, there is one ingredient that is present in every Greenfilled formula, and it plays a key role in preventing the ongoing effects of aging: superoxide dismutase or SOD for short. "We are a brand committed to creating a healthy aging lifestyle," explains Greenfilled COO Enrique Castaño. "All of our products have the same focus, which is to minimize the damages caused by oxidative stress. This is one of the primary health challenges caused by aging." Oxidative stress is a phenomenon that takes place on a cellular level due to imbalances caused by UF, ionizing radiation, heavy metal exposure, and various pollutants. It is a natural occurrence that accelerates the aging process. Naturally, the more oxidative stress is ameliorated, and balance is restored, the longer a body will remain strong and vibrant. Castaño explains that Greenfilled addresses oxidative stress by including its unique form of superoxide dismutase, TetraSOD®, in all of its formulas. TetraSOD® is sourced from sustainably grown phytoplankton and then combined with different ingredients for various uses, such as memory, energy, or performance. No matter what the product's focus may be, though, TetraSOD® is always present, fighting oxidative stress and keeping the body young and firing on all cylinders on a cellular level. "Anyone can benefit from consistently supplementing with SOD," Castaño concludes. "Its ability to counteract oxidative stress and the cost-effective nature of supplementing with something as common as phytoplankton make it one of the best natural anti-aging solutions for those of us trying to stay young and vibrant as we age." About Greenfilled Greenfilled is a health and wellness brand founded by the Spain-based Marine Biotech Company Fitoplancton Marino. The parent company's mission is to research, develop, and supply microalgae-based products that improve health and quality of life. Greenfilled is a manifestation of this mission, with the brand's supplements utilizing sustainably farmed, high-quality phytoplankton that delivers robust levels of the antioxidant enzyme superoxide dismutase (SOD) through its flagship ingredient TetraSOD®. Greenfilled products help with many health concerns, including rest, recovery, energy levels, and cognitive clarity. Learn more at greenfilled.com. Enrique Castaño Sales & Business Development Director Fitoplancton Marino, S.L Phone + 34 620003888 [email protected] SOURCE Greenfilled

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00103012 (CTgov)	临床4期	-	47	Ginkgo Biloba+Lopinavir (Influence of Ginkgo Biloba on Lopinavir Disposition)	艱淵餘網築願簾夢醖夢(鏇夢窪廠願簾顧構觸鬱) = 築觸獵壓構遞鏇願觸蓋鏇廠鹽選鬱選壓衊艱構 (繭鏇繭製積膚鑰鑰簾製, 鏇製積範範顧簾願簾窪 ~ 憲鹹衊淵夢廠憲廠積簾)	-	2012-04-16
				Lopinavir (Influence of Echinacea on Lopinavir Disposition)	艱淵餘網築願簾夢醖夢(鏇夢窪廠願簾顧構觸鬱) = 網憲齋壓壓廠壓積襯壓鏇廠鹽選鬱選壓衊艱構 (繭鏇繭製積膚鑰鑰簾製, 鏇願膚簾觸築夢壓築鑰 ~ 積廠餘醖製窪艱製壓壓)