Present therapy of inflammatory bowel diseases (IBDs) is aimed at relieving inflammation and treating signs and symptoms. Therapy consists of non-specific anti-inflammatory agents, such as 5-aminosalicylic acid, glucocorticoids, immunomodulators and anti-TNF ther-apy. The goals of therapy should include the induction and maintenance of remis-sion and an attempt to heal the mucosa with the ultimate goal being restitution of normal intestinal function. Despite an optimized use of immunosuppressors and the new biologic agents, the need for intes-tinal resection in Crohn’s disease (CD) has remained stable