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更新于：2025-03-20

(-)-Ampelopsin F

更新于：2025-03-20

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点

DPP-4

作用方式

抑制剂

作用机制

DPP-4抑制剂(二肽基肽酶IV抑制剂)

治疗领域

内分泌与代谢疾病

在研适应症

糖尿病

非在研适应症-

原研机构-

在研机构

CSIR-Indian Institute of Chemical Biology

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C28H22O6

InChIKeyLJHNYAXAPRDORG-YFQNEARWSA-N

CAS号354528-90-8

关联

100 项与 (-)-Ampelopsin F 相关的临床结果

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100 项与 (-)-Ampelopsin F 相关的转化医学

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100 项与 (-)-Ampelopsin F 相关的专利（医药）

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项与 (-)-Ampelopsin F 相关的文献（医药）

2024-04-01·Bioorganic & Medicinal Chemistry

An insight into the mechanistic role of (-)-Ampelopsin F from Vatica chinensis L. in inducing insulin secretion in pancreatic beta cells

Article

作者: Abraham, Billu ; Jayamurthy, P ; Lekshmy Krishnan, S ; Radhakrishnan, K V ; Prabha, B

Resveratrol oligomers, ranging from dimers to octamers, are formed through regioselective synthesis involving the phenoxy radical coupling of resveratrol building blocks, exhibiting remarkable therapeutic potential, including antidiabetic properties. In this study, we elucidate the mechanistic insights into the insulin secretion potential of a resveratrol dimer, (-)-Ampelopsin F (AmF), isolated from the acetone extract of Vatica chinensis L. stem bark in Pancreatic Beta-TC-6 cell lines. The AmF (50 µM) treated cells exhibited a 3.5-fold increase in insulin secretion potential as compared to unstimulated cells, which was achieved through the enhancement of mitochondrial membrane hyperpolarization, elevation of intracellular calcium concentration, and upregulation of GLUT2 and glucokinase expression in pancreatic Beta-TC-6 cell lines. Furthermore, AmF effectively inhibited the activity of DPP4, showcasing a 2.5-fold decrease compared to the control and a significant 6.5-fold reduction compared to the positive control. These findings emphasize AmF as a potential lead for the management of diabetes mellitus and point to its possible application in the next therapeutic initiatives.

2022-04-01·Biochemical Systematics and Ecology

Resveratrol oligomers from roots of Ampelocissus martini Planch.

作者: Thanasansurapong, Sariyarach ; Kongkum, Naowarat ; Hongthong, Sakchai ; Wattanakornsiri, Amnuay ; Saekee, Amporn ; Chutimasakul, Threeraphat

Phytochem. investigation of roots of Ampelocissus martini Planch.(Vitaceae family) led to the isolation of five resveratrol oligomers comprising (-)-ampelopsin F (1), (+)-hopeaphenol (2), (-)-α-viniferin (3), (-)-wilsonol A (4) and (-)-stenophyllol B (5).The structure elucidation was performed using their spectroscopic data as well as comparison with those of literature data.All the isolated compounds were submitted to anti-HIV-1 activities employing the syncytium inhibition assay, using the ^ΔTat/RevMC99 virus and 1A2 cell line system, and the reverse transcriptase (RT) assay.The results revealed that the enzymic inhibition of tested compounds except compound 1 exhibited the potential inhibition in anti-HIV 1-RT assay with IC₅₀ in the range of 1.68-5.85μM better than the pos. control, navirapin (IC₅₀ at 7.77μM).Based on the results, their activities displayed the RT enzymic inhibition better than the pos. control.In addition, the chem. isolation of A. martini was studied for the first time herein.All known secondary metabolites except compound 2 were firstly reported from Ampelocissus genus.Furthermore, the chemotaxonomic significance of the isolates was discussed.

2019-08-18·Natural Product Research3区 · 化学

Biologically active oligostilbenes from the stems of Vatica mangachapoi and chemotaxonomic significance

3区 · 化学

Article

作者: Han, Chang-Ri ; Chen, Guang-Ying ; Fu, Yan-Hui ; Bai, Meng ; Wu, Shou-Yuan ; Song, Xiao-Ping ; Zhou, Qi

Phytochemical investigation of the stems of Vatica mangachapoi (Dipterocarpaceae) led to the isolation and structural elucidation of twenty-seven oligostilbenes (1-27), including a new natural compound 1. The structure of 1 was elucidated on the basis of spectroscopic analyses including NMR, MS and ECD data, and the known compounds were identified by comparisons with those reported in the literature. The absolute configuration of 1 was first time determined by a combination of NOESY spectrum and quantum chemical computation. Among of isolates were tested for their anti-osteoporosis and anti-HIV-1 activities in vitro by the MTT method. Moreover, the chemotaxonomic significance of these compounds was summarised.

100 项与 (-)-Ampelopsin F 相关的药物交易

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