Leukotrienes and thromboxane A2 are autacoids derived from arachidonic acid (5,8,11,14-eicosatretraenoic acid).They are synthesized in cells by 5-lipoxygenase and thromboxane synthase, resp.Leukotrienes are related to inflammatory and allergic diseases, while thromboxane A2 is a potent platelet aggregating and vasoconstrictor agent involved in cardiovascular pathologies.In this article the authors have calculated partial potential energy surfaces at the AM1 level for some 5-lipoxygenase inhibitors, thromboxane synthase inhibitors, thromboxane A2 receptor antagonists, and a dual blocker which inhibits thromboxane synthase and antagonizes thromboxane A2 receptor.The objective was to identify stereoelectronic properties and topog. requirements for these compounds that could be related to their biol. activities.Based on the results and on mol. mechanisms of pharmacol. action, the authors were able to propose new potential 5-lipoxygenase inhibitors and dual blockers derived from pyrazole, pyrrole, 1,2,3-triazole, and 1,2,4-triazole.