The Study of Aqueous Extract of Puerariae Radix. IV. The Isolation of Daidzin from the Active Extract (MTF-101) and Its Antifebrile and Spasmolytic Effect

4区 · 医学

Article

作者: Iwasaki, Yuki ; Kizu, Haruhisa ; Nakamoto, Hiromasa

From the aqueous extract (MTF-101) of Puerariae radix, daidzin (I) [552-66-9] and daidzein-7-glucoside [552-66-9] were isolated.The hypothermic effect of I on rats and its spasmolytic effect on mice were examined in comparison with those of daidzein.Neither I nor daidzein showed a hypothermic effect in rats in a dose of 30 mg/kg s.c.Daidzein showed about 1/3 the spasmolytic effect of papaverine on the small intestine of mice, but I showed no spasmolytic effect.

1975-01-01·YAKUGAKU ZASSHI

The Study of the Aqueous Extract of Puerariae Radix. I. The Preparation and the Components of the Active Extract

Article

作者: Miyamura, Soji ; Nakamura, Nobuko ; Inada, Kazuyoshi ; Nakamoto, Hiromasa

From the aqueous extract of Puerariae radix, anticholinergic substances like daidzein, daidzin, and puerarin were removed as much as possible to make a syrup material which has a constant cholinergic activity.This sirup material was termed MTF-101.From MTF-101, two cholinergic substances and five other compounds were isolated; choline chloride [67-48-1] (∼1.0%), acetylcholine chloride [60-31-1] (∼0.1%), allantoin [97-59-6] (∼3%), D-mannitol [69-65-8] (∼15%), D-(+)-pinitol [10284-63-6] (∼8%), succinic acid [110-15-6] (∼10%), and L-(+)-Mg lactate [18917-93-6] (∼15%).

1975-01-01·YAKUGAKU ZASSHI

葛根の水溶性抽出物の研究(第2報)葛根の活性エキス(MTF-101)とアセチルコリンとの生物学的相違について

Article

作者: Iwasaki, Yuki ; Saito, Haruo ; Nakamoto, Hiromasa

The difference of stability was compared between the aqueous extract of Puerariae radix MTF-101 [57455-79-5], was much more resistant to cholinesterase [9001-08-5] and high temperature, and more effective on the intestinal movement of anesthetized guinea pig and intestinal internal pressure than acetylcholine chloride [60-31-1] (1 × 10-7 g/ml).

100 项与 MTF-101 (Motif Bio) 相关的药物交易

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