NOX-100(NOX-100) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

Norathiol

靶点-

作用方式

抑制剂

作用机制

一氧化氮抑制剂

治疗领域

感染心血管疾病其他疾病

在研适应症-

非在研适应症

低血压脓毒性休克

原研机构

Medinox, Inc.

在研机构-

非在研机构

友华生技医药股份有限公司

Medinox, Inc.

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式C8H17NO5S2

InChIKeyIBVJFULICYLKCE-BDVNFPICSA-N

CAS号94161-07-6

查看全部结构式(2)

关联

1

项与 NOX-100 相关的临床试验

NCT01672008

/ Completed临床2期

A Phase IIa Study of Safety and Efficacy of NOX-100 for Preventing Hypotension in Patients During Hemodialysis Sessions

This study is designed to evaluate the safety, tolerability and efficacy profile of NOX-100 to reduce intradialytic hypotension (IDH) in patients undergoing chronic hemodialysis (HD).

开始日期2012-08-01

申办/合作机构

Medinox, Inc.

[+1]

100 项与 NOX-100 相关的临床结果

登录后查看更多信息

100 项与 NOX-100 相关的转化医学

登录后查看更多信息

100 项与 NOX-100 相关的专利（医药）

登录后查看更多信息

120

项与 NOX-100 相关的文献（医药）

2021-03-01·Cell Biochemistry and Biophysics4区 · 生物学

Nitrosonium Cation as a Cytotoxic Component of Dinitrosyl Iron Complexes with Thiol-containing Ligands (based on the Experimental Work on MCF7 Human Breast Cancer Cell Culture)

4区 · 生物学

Article

作者: Tronov, Viktor A ; Borodulin, Rostislav R ; Vanin, Anatoly F

Here we demonstrate that binuclear dinitrosyl iron complexes with thiol-containing ligands (glutathione and mercaptosuccinate, B-DNIC-GSH and B-DNIC-MS, respectively) exert cytotoxic effects on MCF7 human breast cancer cells. We showed that they are mediated by nitrosonium cations released from these complexes (NO⁺). This finding is supported by the cytotoxic effect of both B-DNICs on MCF7 cells evidenced to retain or was even promoted in the presence of N-Methyl-D-glucamine dithiocarbamate (MGD). MGD recruits an iron nitrosyl group [Fe(NO)] from the iron-dinitrosyl fragment [Fe(NO)₂] of B-DNIC-MS forming stable mononitrosyl complexes of iron with MGD and releasing NO⁺ cations from a [Fe(NO)₂] fragment.

2020-11-01·Journal of Synthetic Organic Chemistry, Japan

Development of Photoredox-reaction-driven NO-releasing Reagents and Application for Photomanipulation of Vasodilation

作者: Nakagawa, Hidehiko ; Ieda, Naoya

Nitric oxide (NO) is a signaling mol. that mediates vasodilation, neurotransmission, and immune response.Due to its instability in biol. environments, NO-releasing small-mol. compounds have been developed for biol. experiments and also as therapeutic reagents for vascular diseases.Although photocontrollable NO releasers are very useful chem. tools because of their precise operability in response to light irradiation, their biol. applications have been limited, mainly because they require UV light irradiation or contain metal ions with the potential to cause cytotoxicity.In order to overcome these problems, our group has developed visible-light-responsive NO releasers based on photoreodox reaction.These compounds are composed of two moieties, an NO-releasing moiety and a light-harvesting antenna moiety.After photoirradiation, photoinduced electron transfer from the NO releasing moiety to the antenna takes place, followed by NO release.Based on this system, we developed a blue-light-controllable NO releaser and a yellowish-green-light-controllable one, which are applicable for cellular and ex vivo experimentsThis account focuses on recent developments in photoredox-driven NO releasers and their applications for spatiotemporally controlled NO release in cells and ex vivo.

2018-09-01·Applied and Environmental Microbiology2区 · 生物学

Mechanism of Virus Inactivation by Cold Atmospheric-Pressure Plasma and Plasma-Activated Water

2区 · 生物学

Article

作者: Gou, Lu ; Liu, Zhichao ; Xu, Ruobing ; Kong, Michael G. ; Zhang, Lei ; Guo, Li ; Liu, Dingxin ; Chen, Hailan ; Zhao, Yiming

Contamination with pathogenic and infectious viruses severely threatens human health and animal husbandry. Current methods for disinfection have different disadvantages, such as inconvenience and contamination of disinfection by-products (e.g., chlorine disinfection). In this study, atmospheric surface plasma in argon mixed with air and plasma-activated water was found to efficiently inactivate bacteriophages, and plasma-activated water still had strong antiviral activity after prolonged storage. Furthermore, it was shown that bacteriophage inactivation was associated with damage to nucleic acids and proteins by singlet oxygen. An understanding of the biological effects of plasma-based treatment is useful to inform the development of plasma into a novel disinfecting strategy with convenience and no by-product.

100 项与 NOX-100 相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB05799

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
低血压	临床2期	中国台湾	友华生技医药股份有限公司	2012-08-01
低血压	临床2期	中国台湾	Medinox, Inc.	2012-08-01
脓毒性休克	临床2期	-	友华生技医药股份有限公司	-