CCR8 Mab (Vaccinex)(CCR8 Mab (Vaccinex)) - 药物靶点：CCR8_在研适应症：肿瘤_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名-

靶点

CCR8

作用方式

抑制剂

作用机制

CCR8抑制剂(C-C chemokine receptor type 8 inhibitor)

治疗领域

肿瘤

在研适应症

肿瘤

非在研适应症-

原研机构

Vaccinex, Inc.

在研机构

Vaccinex, Inc.

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 CCR8 Mab (Vaccinex) 相关的临床结果

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100 项与 CCR8 Mab (Vaccinex) 相关的转化医学

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100 项与 CCR8 Mab (Vaccinex) 相关的专利（医药）

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1

项与 CCR8 Mab (Vaccinex) 相关的文献（医药）

2022-04-01·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

C₈Mab-2: An Anti-Mouse C–C Motif Chemokine Receptor 8 Monoclonal Antibody for Immunocytochemistry

Article

作者: Tanaka, Tomohiro ; Kato, Yukinari ; Tateyama, Nami ; Nakamura, Takuro ; Komatsu, Yu ; Nanamiya, Ren ; Li, Guanjie ; Asano, Teizo ; Handa, Saori ; Yanaka, Miyuki ; Harigae, Yasuhiro ; Suzuki, Hiroyuki ; Saito, Masaki ; Kaneko, Mika K.

C-C motif chemokine receptor 8 (CCR8) is a G protein-coupled receptor predominantly expressed in regulatory T (Treg) and T helper 2 cells. The evidence that CCR8 expression in Treg is increased in cancers, CCR8 increases migration activity of Treg, and CCR8 induces the anti-apoptotic activity in T cell leukemia and lymphoma suggests that CCR8 is associated with cancer development. Thus, developing a specific monoclonal antibody (mAb) for CCR8 is useful for diagnostic and therapeutic purposes and the anti-CCR8 mAb becomes a remarkable experimental tool for basic research. We previously developed an anti-mouse CCR8 (mCCR8) mAb called C₈Mab-2 (rat IgG_2b, kappa) that was applicable to flow cytometric analysis for both endogenous and exogenous mCCR8. This study showed that C₈Mab-2 and recombinant C₈Mab-2 (recC₈Mab-2) were specifically bound to exogenously expressed mCCR8 in mCCR8-overexpressed Chinese hamster ovary-K1 cells. In addition, we found that C₈Mab-2 and recC₈Mab-2 recognized endogenous mCCR8 in P388 (a mouse lymphocyte-like cell line) and J774-1 cells (a mouse macrophage-like cell line). These data demonstrate that C₈Mab-2 and recC₈Mab-2 are useful for immunocytochemical analysis.

100 项与 CCR8 Mab (Vaccinex) 相关的药物交易

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