Nanocurcumin(Tehran University of Medical Sciences)(Nanocurcumin(Tehran University of Medical Sciences)) - 在研适应症：肿瘤，类风湿关节炎，实体瘤_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域

肿瘤免疫系统疾病皮肤和肌肉骨骼疾病

在研适应症

肿瘤类风湿关节炎实体瘤

非在研适应症-

原研机构

Tehran University of Medical Sciences

在研机构

JYANT Technologies, Inc.

Tehran University of Medical Sciences

非在研机构-

最高研发阶段临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

24

项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的临床试验

IRCT20160809029275N4 / Suspended临床1期IIT

Investigating the simultaneous effect of intrathecal and intravenous injection of autologous mesenchymal stem cells and nanocurcumin consumption in patients with Amyotrophic Lateral Sclerosis (ALS)

开始日期2024-06-21

申办/合作机构

Mashhad University of Medical Sciences

IRCT20240208060938N1 / Suspended临床3期IIT

Investigating the effect of nano curcumin supplementation on drug craving, psychotic symptoms and serum levels A2A, TLR4 receptors and TNF-alpha, IL-6 factors in psychotic methamphetamine consuming patients.

开始日期2024-04-03

申办/合作机构

Kashan University of Medical Sciences

IRCT20220420054592N2 / Recruiting临床2期IIT

Comparing the effect of mouthwash containing curcumin and oral nanocurcumin on gingivitis in patients with chronic gingivitis who referred to Dental School of Shahid Sadoughi

开始日期2024-02-26

申办/合作机构-

100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的临床结果

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100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的转化医学

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100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的专利（医药）

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292

项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的文献（医药）

2024-10-17·Photodiagnosis and photodynamic therapy

Evaluation of riboflavin, nanocurcumin, and hydrogen peroxide under light conditions: reduction of mature dental biofilms and enamel mineral loss.

Article

作者: Chiniforush, Nasim ; Omrani, Ladan Ranjbar ; Afrasiabi, Shima ; Gburi, Ahmed Qays Khudhur Al ; Moradi, Zohreh

BACKGROUNDBiofilms are a potential harbor for many microorganisms. The aim of this study was to test the efficacy of riboflavin (Rib), nano-micelle curcumin (NC), and hydrogen peroxide (HP), alone and in combination with the respective light (light-emitting diode (LED) or 980 nm diode laser) on the reduction of Streptococcus mutans and Lactobacillus acidophilus dual-species biofilms and their effect on the enamel mineral loss.MATERIALS AND METHODSThe biofilms were formed on saliva-coated enamel slabs. Then, the biofilms were treated with antimicrobial photodynamic therapy (PDT) based on LED, Rib, and NC photosensitizers and with HP also based on a 980 nm diode laser (n = 8 per group). A crystal violet assay was performed to determine the reduction of the dual-species biofilms. The enamel slabs were analyzed for calcium and phosphorus content by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX).RESULTSWhile HP-PDT showed a reduction of 37% (p < 0.001), PDT with NC resulted in an even greater reduction of dual-species biofilms (40%, p < 0.001) than HP- and Rib-mediated PDT. In the EDX test, no significant difference was found between the control group and the treatment groups.CONCLUSIONSThe use of natural photosensitizers such as NC in PDT has an effect that may be potentially important in reducing caries-causing bacteria.

2024-10-01·Anti-Cancer Drugs

Is oral nano-curcumin formulation a safe and effective measure for preventing cisplatin-induced nephrotoxicity in cancer patients?

Article

作者: Rahsepar, Sara ; Elyasi, Sepideh ; Naghipour, Sara ; Hosseini, Sare

Nephrotoxicity is one of the most important complications in cancer patients under treatment with cisplatin-containing regimens. Curcumin, as the most important active component of Curcuma longa, is an antioxidant and anti-inflammatory compound. In this clinical trial, we assessed the preventive effect of nano-curcumin oral formulation against cisplatin-induced nephrotoxicity in cancer patients. In this triple-blind clinical trial 30 cancer patients on cisplatin were randomly included in the treatment group, receiving nano-curcumin 40 mg capsules (n = 15) or the placebo group (n = 15) twice a day during four chemotherapy courses. Kidney function was measured at the beginning of the study and then at the end of each course of chemotherapy. There was no significant difference in acute kidney injury occurrence rate and creatinine and blood urine nitrogen serum levels between the treatment and placebo groups at the end of each chemotherapy course (P value >0.05). Just at the end of the first course, the difference was close to significant (P = 0.055). We also found no difference in mortality and recurrence rate in an average 30-month follow-up. Nano-curcumin in the prescribed dose and duration was not effective in preventing cisplatin-induced nephrotoxicity in cancer patients in comparison with the placebo. Further studies with larger sample size using different doses and duration of nano-curcumin are recommended.

2024-10-01·Pharmaceutical Nanotechnology

An Oxidative Stress Study on Curcumin and NanoCurcumin against Aluminum Phosphide-induced Kidney Injury in Rats: The Role of SIRT1/FOXO3 Signaling Pathway in Nephrotoxicity

Article

作者: Abdolvahab, Mohadeseh Haji ; Kheiripour, Nejat ; Jouzdani, Ali Fathi ; Ranjbar, Akram ; Asl, Sara Soleimani ; Ghasemi, Hassan ; Manesh, Seyde Farnaz Motevali

Introduction:In this study, we have investigated the aluminium phosphide (ALP) toxicity on Renal Function and oxidative stress in kidney tissue of male rats and the possible protective role of Curcumin and nanoCurcumin against ALP-induced nephrotoxicity.Methods:Thirty-six adult male rats were divided into 6 groups (n=6). ALP (2 mg/kg oral administration) and control groups received Curcumin and nanoCurcumin (oral administration 100 mg/kg) or without it. After seven days of treatment, kidney parameters, oxidative stress biomarkers, and expression level of sirtuins1 (SIRT1)/Forkhead box protein O1 (FoxO1) pathway genes were evaluated in kidney tissue. In addition, histopathological changes in the kidney tissues were assayed.Results:In the ALP group, compared to the control group, lipid peroxidation levels, urea, and creatinine were increased, and total antioxidant capacity and thiol groups decreased significantly p < 0.05. In Curcumin and nanoCurcumin groups compared to the ALP group, lipid peroxidation and creatinine decreased significantly p < 0.05. Also, Curcumin and nanoCurcumin improved the tissue damage caused by ALP. NanoCurcumin modulated the effect of ALP on the gene expression levels in SIRT1/FoxO1.Conclusion:The present study showed that ALP intoxication in kidney tissue can induce oxidative damage. Moreover, Curcumin and nanocurcumin, as potential antioxidants, can be effective therapeutics in ALP-induced nephrotoxicity.

100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的药物交易

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