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更新于：2025-05-07

B-823-10

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

2-[(4-methoxy-3-methyl-2-pyridylmethyl)-thio]-5-trifluoromethyl-(1H)-benzimidazole

靶点

Proton pump

作用方式

抑制剂

作用机制

质子泵抑制剂

治疗领域-

在研适应症-

非在研适应症-

原研机构

ALTANA Pharma AG

在研机构

ALTANA Pharma AG

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C16H14F3N3O2S

InChIKeyOWWKQFJLNQHYQS-UHFFFAOYSA-N

CAS号86604-68-4

关联

100 项与 B-823-10 相关的临床结果

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100 项与 B-823-10 相关的转化医学

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100 项与 B-823-10 相关的专利（医药）

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项与 B-823-10 相关的文献（医药）

2004-02-01·Amino Acids3区 · 生物学

Inhibition of the L-dopa transport system in human epidermal Langerhans cells by omeprazole and its analogues

3区 · 生物学

Article

作者: Niels Bendsöe ; G Ronquist

L-3,4-dihydroxyphenylalanine (L-dopa) transport into human Langerhans cells (LC) occurs by a saturable mediation. This plasma membrane agency is, due to its characteristics, distinguishable from systems transporting other neutral, cationic and anionic amino acids into other cells and serves to catalyze the flow of L-dopa, only, into LC. The uphill operation of this L-dopa transport system is believed to occur by down-gradient countermigration of H(+). Due to the uniqueness of the L-dopa transport system, the widely used analogue inhibition approach was not applicable. Instead we studied omeprazole and its analogues in our search for suitable inhibitory candidates. Omeprazole and most of its analogues were indeed inhibitory in the concentration range 1-100 micromol/L. Conspicuously, the compounds with strongest polarity were least inhibitory. The inhibitory pattern displayed by omeprazole and the other analogues on L-dopa uptake in LC corresponded to some extent to what has been observed previously for purified H(+),K(+)-ATPase from tubulovesicles of the stomach. No effects of the inhibitors were registered on energy charge and lactate production of epidermal biopsies, nor were any gross alterations of ultrastructure of LC noticed.

1990-06-01·The Journal of Organic Chemistry

(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 3. Evidence for the involvement of a sulfenic acid in their reactions

作者: Senn-Bilfinger, Joerg ; Rainer, Georg ; Schaefer, Hartmann ; Sturm, Ernst ; Kohl, Bernhard ; Krueger, Uwe ; Klemm, Kurt ; Figala, Volker ; Blake, Timothy J.

The title compounds I (R = H, R¹ = CF₃, R² = R⁵ = H, R³ = Me, R⁴ = OMe; R = H, R¹ = OMe, R² = H, R³ = R⁵ = Me, R⁴ = OMe) undergo acid-induced transformations into the cyclic sulfenamides II via the putative sulfenic acids III.At high concentrations mixtures of II and thiolsulfinates IV (n = 1) were obtained.In contrast, I (R = CF₃, R¹ = H, R² = R³ = Me, R⁴ = OMe, R⁵ = H), which cannot form II, is completely transformed under similar conditions into IV (n = 1), the anhydride of III.The temperature-dependent equilibrium between II and IV (n = 1) and the kinetics of the ring opening of II by water provide evidence for the sulfenic acid III as an intermediate involved in the pH-dependent transformations of I.IV (n = 1) decompose mainly to the disulfides IV (n = 0) at a rate depending on the solvent and conditions and are also reduced to disulfides by thiols.

1989-01-01·Acta Chemica Scandinavica

Chemical Reactions of Omeprazole and Omeprazole Analogues. II. Kinetics of the Reaction of Omeprazole in the Presence of 2-Mercaptoethanol.

作者: Larsson, Sam ; Skånberg, Inger ; Brändström, Arne ; Erickson, Magnus ; Persson, Björn ; Löfberg, Ingalil ; Hagin, Inger ; Johansson, Svante ; Ohlson, Kristina ; Bergman, Nils-Åke ; Tekenbergs-Hjelte, Lija ; Alminger, Tomas ; Grundevik, Inger ; Hoffman, Kurt-Jürgen ; Lindberg, Per

The rate at which omeprazole (I) reacts with 2-mercaptoethanol is equal to the rate at which it converted to a sulfenamide.This reaction proceeds via two intermediates, a spiro compound and a sulfenic acid.A kinetic study of the reaction at different pH values revealed that the conversion to the spiro compound is the slowest step.It can be an uncatalyzed reaction, but can also be acid-catalyzed.Even the conversion of the spiro compound to the sulfenic acid can occur by an uncatalyzed reaction as well as by an acid-catalyzed one.The conversion of the sulfenic acid to the sulfenamide is very rapid.The rate constants for the different steps can usually be predicted.

100 项与 B-823-10 相关的药物交易

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