NP-02(CNBX Pharmaceuticals)

Analgesic, antiinflammatory and antiulcer activity of newly synthesized nitric oxide (NO) releasing ester derivatives of indomethacin were evaluated in rats. Synthetic compounds (NB-02, NP-02 and NE-02) 6 mg/kg, po each significantly (P < 0.01) increased the tail flick reaction time in rats. Antinociceptive effects of two derivatives (NB-02 and NE-02) were compared to that of the parent compound. Indomethacin derivatives (NB-02, NP-02 and NE-02) exhibited significant (P < 0.01) anti-inflammatory activity as observed in carrageenan induced rat paw inflammatory model. The severity of gastric lesion were also significantly (P < 0.01) less in animals treated with ester derivatives of indomethacin (NB-02, NP-02 and NE-02) as compared to mo-control.