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更新于：2025-03-20

4,4′-Methylenediphenol

更新于：2025-03-20

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病

在研适应症

阿尔茨海默症

非在研适应症-

原研机构-

在研机构

云南中医药大学

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

结构/序列

分子式C13H12O2

InChIKeyPXKLMJQFEQBVLD-UHFFFAOYSA-N

CAS号620-92-8

关联

100 项与 4,4′-Methylenediphenol 相关的临床结果

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100 项与 4,4′-Methylenediphenol 相关的转化医学

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100 项与 4,4′-Methylenediphenol 相关的专利（医药）

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1,885

项与 4,4′-Methylenediphenol 相关的文献（医药）

2025-06-01·Separation and Purification Technology

Highly dispersed single-atom Fe and Fe3O4 clusters anchored hierarchical-pore carbon as efficient persulfate activation catalyst

作者: Zhao, Cheng ; Wang, Qing ; Yin, Yi ; Zheng, Guangming ; Lin, Jiawei ; Dai, Xiaoxin ; Zhang, Hongfeng ; Hu, Yongyou ; Zhou, Hao ; Wei, Linting

The selective removal of Fe particles from carbonized Fe-MOFs presents an intriguing strategy for developing efficient peroxydisulfate (PDS) activators.It is commonly accepted that their outstanding performance is largely attributed to the high sp. surface area/pore volumeHowever, our investigation into the structure-function relationship of these materials has revealed new insights.In this study, a highly dispersed single-atom Fe and Fe₃O₄ clusters anchored hierarchical-pore carbon (CM88-H) was obtained via post-acid treatment of carbonized MIL-88B (CM88).Various characterizations were comparatively conducted to highlight the beneficial effects of iron dissolutionThe CM88-H/PDS system achieved a notable BPA degradation efficiency, with a reaction rate of 0.323 min^-1, which is 3.94 times higher than that of the CM88/PDS system.DFT calculations indicate that the Fe₃O₄ clusters optimize the charge distribution around single-atom Fe, promoting favorable PDS adsorption and facilitating a higher oxidation state of CM88-H.As a result, BPA can be completely degraded within 10 min with 0.1 g L^-1 CM88-H and 0.05 g L^-1 PDS via both radical and non-radical pathways.The CM88-H/PDS/BPA system performs effectively under various conditions, with a general reduction in toxicity.Furthermore, the CM88-H/PDS system shows broad oxidation activity towards BPA substitutes and pollutants with high ionization potential (IP).Notably, the CM88-H sponge-based fixed-bed catalytic reactor demonstrated satisfactory BPA degradation, highlighting the promising application of CM88-H in water purificationThis study provides a sustainable solution for water treatment and accelerates the practical application of powd. nanocatalysts to improve water quality.

2025-04-01·Talanta

Graphyne-supported manganese single-atom nanozyme sensor array for bisphenol identification

Article

作者: Li, Zhen ; Ye, Daixin ; Zhao, Hongbin ; Ding, Yaping ; Xia, Jianing ; Fu, Ruixue

Bisphenols, as common industrial raw materials, are widely used in food packaging such as plastics. However, their migration and residue may affect the hormone secretion of the human body and then lead to health problems. Therefore, a low-cost, rapid and simple detection method that can simultaneously detect multiple bisphenols is very necessary. In this work, two types of manganese single-atom nanozymes with excellent peroxidase-like activity were synthesized with graphyne as a support. A high-throughput colorimetric sensor array was constructed using three types of nanozymes (Mn-GY, Mn-GY-2N, GY-2N) to distinguish various bisphenols. Due to the absorption of bisphenol molecules on the surface of nanozymes, the activity of nanozymes decreases differently, when different bisphenols are added to the catalytic system. The results proved that the prepared sensor had good linear relationships at both low and high concentrations for determination of five bisphenols. The LODs of BPA, BPS, BPF, BPAF, and Diphenolic Acid were 0.443, 0.280, 0.277, 0.424, and 0.326 μM respectively. Compared with traditional sensors, the sensor array can simultaneously detect multiple analytes with high throughput, showing great advantage in dealing with complex samples. Combined with machine learning algorithms, five bisphenols can be successfully identified by the obtained array data. The sensor array also demonstrated excellent performance in the detection of both mixed samples and real samples. This high-throughput colorimetric sensor array achieves accurate and sensitive detection of bisphenol substances, providing new means and ideas for enhancing food safety. At the same time, the simple and rapid identification of structurally similar compounds demonstrates its potential for more precise analysis, providing possibilities for future development.

2025-03-01·Food and Chemical Toxicology

Impact of endocrine disruptors on key events of hepatic steatosis in HepG2 cells

Article

作者: Grosso, Marina F ; Babica, Pavel ; Sovadinová, Iva ; Řehůřková, Eliška ; Virmani, Ishita ; Sychrová, Eliška

Endocrine-disrupting chemicals (EDCs) may contribute to the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the potential of 10 environmentally relevant EDCs to affect key events of hepatic steatosis in HepG2 human hepatoblastoma cells. Increased lipid droplet formation, a key marker of steatosis, was induced by PFOA, bisphenol F, DDE, butylparaben, and DEHP, within the non-cytotoxic concentration range of 1 nM-25 μM. Cadmium also induced this effect, but at concentrations impairing cell viability (>1 μM). At non-cytotoxic concentrations, these compounds, along with bisphenol A, dysregulated major genes controlling lipid homeostasis. Cadmium, PFOA, DDE, and DEHP significantly upregulated the DGAT1 gene involved in triglyceride synthesis, while butylparaben increased the expression of the FAT/CD36 gene responsible for fatty acid uptake. Bisphenol A downregulated the CPT1A gene involved in fatty acid oxidation. No significant effects on lipid droplet accumulation or lipid metabolism-related genes were observed for PFOS, bisphenol S, and dibutyl phthalate. Among the tested EDCs, lipid accumulation positively correlated with the expression of SREBF1, DGAT1, and CPT1A. These findings provide additional evidence that EDCs can affect MASLD and highlight the utility of in vitro methods in the screening of EDCs with hazardous steatogenic and metabolism-disrupting properties.

100 项与 4,4′-Methylenediphenol 相关的药物交易

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