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更新于：2025-03-20

NAI-Acne

更新于：2025-03-20

概要

概要

基本信息

药物类型

化学药

别名

BI-Acne、NAI Acne、VIC-acne

+ [4]

靶点

EEF1A1

作用方式

抑制剂

作用机制

EEF1A1抑制剂(伸长因子-1-α1抑制剂)

治疗领域

皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

寻常痤疮

原研机构

Pfizer Inc.

在研机构-

非在研机构

Naicons Srl

Pfizer Inc.

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C60H60N14O8S6

InChIKeyUKCJXGLXMXXQNR-KBMLLTHISA-N

CAS号634602-12-3

关联

项与 NAI-Acne 相关的临床试验

EUCTR2014-001491-62-SK

/ Not yet recruiting临床2期

Clinical efficacy and safety of NAI-Acne gel 3% applied twice-a-day to patients with facial acne vulgaris - NAI-003 3% gel efficacy pilot

开始日期2014-08-11

申办/合作机构

Naicons Srl

100 项与 NAI-Acne 相关的临床结果

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100 项与 NAI-Acne 相关的转化医学

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100 项与 NAI-Acne 相关的专利（医药）

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项与 NAI-Acne 相关的文献（医药）

2015-08-01·Antimicrobial Agents and Chemotherapy2区 · 医学

A Derivative of the Thiopeptide GE2270A Highly Selective against Propionibacterium acnes

2区 · 医学

Article

作者: Sosio, Margherita ; Spurio, Roberto ; Maffioli, Sonia ; Fabbretti, Attilio ; Jabes, Daniela ; He, Cheng-Guang ; Donadio, Stefano ; Brandi, Letizia ; Gaspari, Eleonora

ABSTRACT A chemical derivative of the thiopeptide GE2270A, designated NAI003, was found to possess a substantially reduced antibacterial spectrum in comparison to the parent compound, being active against just a few Gram-positive bacteria. In particular, NAI003 retained low MICs against all tested isolates of Propionibacterium acnes and, to a lesser extent, against Enterococcus faecalis . Furthermore, NAI003 showed a time- and dose-dependent killing of both a clindamycin-resistant and a clindamycin-sensitive P. acnes isolate. Gel shift experiments indicated that, like the parent compound, NAI003 retained the ability to bind to elongation factors Tu (EF-Tus) derived from Escherichia coli , E. faecalis , or P. acnes , albeit with reduced efficiency. In contrast, EF-Tus derived from the NAI003-insensitive Staphylococcus aureus or Streptococcus pyogenes did not bind this compound. These results were confirmed by in vitro studies using a hybrid translation system, which indicated that NAI003 can inhibit most efficiently protein synthesis driven by the P. acnes EF-Tu. P. acnes mutants resistant to NAI003 were isolated by direct plating. With one exception, all analyzed strains carried mutations in the tuf gene, encoding EF-Tu. Because of its selective effect on P. acnes in comparison to resident skin flora, NAI003 represents a promising candidate for the topical treatment of acne, which has already completed a phase 1 clinical study.

1990-01-01·Gigiena truda i professional'nye zabolevaniia

Toksichnost' ĭodida tseziia, ĭodida natriia i ĭodida tseziia, aktivirovannogo ĭodidom natriia.

Article

作者: Fadeev, A I ; Gerasimova, I L

1972-02-01·Il Farmaco; edizione pratica

[Formulation and stabilization of magistral collyria].

Article

作者: Henschel, V

100 项与 NAI-Acne 相关的药物交易

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