作者: Ni, Junjun ; Tang, Ben Zhong ; Zhang, Jianyu ; Fang, Huaquan ; Xu, Feng ; Kwok, Ryan T K ; Lam, Jacky W Y ; Liu, Wenjing ; Guo, Xiaoyu ; Jin, Guorui ; Hu, Zhongyan

Organic photosensitizers (PSs) with long-lived charge-separated states (CSs) are optimal for converting photonic energy into reactive oxygen species (ROS) by maximizing the interaction between excited electrons and holes in subsequent photoreactions. However, the substantial consumption of oxygen by the singlet oxygen species produced by these PSs can significantly impede their anticancer efficacy, because of the hypoxia nature of solid tumors. Herein, we present a rational strategy for the structural modification of the well-known Fukuzumi acridinium salt (9-mesityl-10-methylacridinium ion) with long-lived CSs, by incorporating a methyl-substituted diphenylamine group (named MTPAA). This modification significantly enhances type-I ROS generation. The "methyl effect" in MTPAA has distinguished merits of stabilized radical species through resonance, leading to an over 8-fold increase in type-I ROS generation compared to TPAA, which lacks the methyl group. Moreover, cellular experiments show that MTPAA with the "methyl effect" significantly enhances photodynamic therapy efficacy under hypoxic conditions. Our molecular design strategy offers a promising approach to creating high-performance type-I PSs and is anticipated to inspire broader exploration in other photosensitizer systems with long-lived CSs, serving as a versatile strategy for advancing type-I PS development.

2025-04-07·ACS Materials Letters

Tailoring Molecular Conjugation Size for Efficient Defect Passivation in Perovskite Photovoltaics

作者: Dodoo-Arhin, David ; Bian, Xiaolong ; Fan, Lisha ; Zhang, Tao ; Chen, Ting ; Lu, Guochao ; Zhou, Kun ; Xu, Gaopeng ; Pan, Shicheng ; Chen, Xiuyuan ; Li, Jing ; Xu, Gang ; Yu, Jiewen ; Zhang, Zenan ; He, Qingquan ; Chen, An ; Pan, Jun ; Agyei-Tuffour, Benjamin

Film surface defects impede the performance of perovskite solar cells.Conjugated mols. with electron-donating/withdrawing groups have demonstrated efficacy in passivating these defects.However, the influence of the conjugated backbone on the passivation state of functional groups has remained insufficiently explored.In this study, we investigated the passivation effectiveness of C=O and N-H groups in different conjugated environments using 2,3-dihydroquinolin-4(1H)-one (DQLO), quinolin-4(1H)-one (QLO), and acridin-9(10H)-one (ADO).Our findings revealed that underconjugated DQLO failed to passivate and even diminished the device performance.Conversely, the larger conjugated ADO led to an averaged electron d. distribution and self-aggregation, reducing passivation effectiveness.Optimal passivation was achieved with QLO, resulting in a power conversion efficiency of 23.05% and enhanced stability, retaining 89.0% of initial performance after 1050 h at 30% R.H. and 92.1% after 230 h at 70 °C in N₂.This research underscores the crucial role of conjugated backbones in enhancing the mol. passivation efficiency.

2025-02-01·Biochimica et Biophysica Acta (BBA) - General Subjects

Insight into the intercalation of N-substituted acridine-9-amines into DNA based on spectroscopic and calorimetric analysis

Article

作者: Wyrzykowski, Dariusz ; Milaș, Dan ; Żamojć, Krzysztof ; Mańkowska, Magdalena ; Grabowska, Ola ; Krzymiński, Karol

The study delves into the binding properties of acridine-9-amine and its selected, mainly N-substituted derivatives (A9As), with calf thymus deoxyribonucleic acid (CT-DNA). This investigation, conducted using UV-Vis spectrophotometry, steady-state fluorescence spectroscopy and isothermal titration calorimetry, provides insights into the relationship between their structure and activity. The absorption spectra of the A9As exhibited a slight red shift and significant hypochromic effects, while the fluorescence emission intensities decreased in the presence of CT-DNA. These results suggest that all fluorescent substrates intercalate into the double helix of native DNA to varying degrees. The binding constants for the A9As/CT-DNA complexes (log(K_A) were determined using various techniques in the range from 2.59 to 5.50). The thermodynamic parameters of A9As binding to DNA were obtained from ITC measurements (ΔG from - 7.51 to - 6.75 kcal·mol^-1, ΔH from - 11.58 to - 3.83 kcal·mol^-1, and TΔS from - 4.83 to 3.68 kcal·mol^-1) and indicated that the formation of all the investigated A9As-DNA complexes is an enthalpy-driven process. The study also discusses the influence of the emitters' structure and electronic properties of substituents on intercalation efficiency. This knowledge serves as a guide for further research and offers directions for functionalising new acridines as potential reagents. It also provides the latest information on the ability of intercalation to DNA, which can be instrumental in studies on the mechanism of binding small aromatic molecules to DNA and can potentially contribute to new anticancer drug designs.

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适应症	最高研发状态	国家/地区	公司	日期
肿瘤	临床申请	美国	Jubilant Therapeutics, Inc.	2024-06-15
实体瘤	药物发现	-	Jubilant Biosys Ltd.	2020-08-02
实体瘤	药物发现	美国	Checkpoint Therapeutics, Inc.	2020-08-02