This phase III trial compares rose geranium in sesame oil nasal spray to isotonic nasal saline in improving symptoms of nasal vestibulitis in cancer patients receiving chemotherapy. Nasal (nose) symptoms (dryness, discomfort, bleeding, scabbing or sores) due to inflammation, termed nasal vestibulitis, is reported as a side effect of cancer-directed therapy. Rose geranium in sesame oil nasal spray may work better than isotonic nasal saline in improving symptoms of nasal vestibulitis.

开始日期2020-11-13

申办/合作机构

Mayo Clinic

[+1]

100 项与玫瑰和天竺葵提取物相关的临床结果

登录后查看更多信息

100 项与玫瑰和天竺葵提取物相关的转化医学

登录后查看更多信息

100 项与玫瑰和天竺葵提取物相关的专利（医药）

登录后查看更多信息

项与玫瑰和天竺葵提取物相关的文献（医药）

2020-12-01·BMJ supportive & palliative care3区 · 医学

Rose geranium in sesame oil nasal spray: a treatment for nasal vestibulitis?

3区 · 医学

Article

作者: Cathcart-Rake, Elizabeth J ; Zahrieh, David ; Loprinzi, Charles L ; Smith, Deanne

Objectives:

As a rose geranium in sesame oil spray product has been anecdotally noted to improve nasal vestibulitis symptoms, this study was designed to assess whether patients with nasal vestibulitis associated with cancer-directed therapy experienced symptomatic improvements from it.

Methods:

Patients with breast cancer, prescribed rose geranium nasal spray, were identified by looking at pharmacy records and patient diagnosis at Mayo Clinic Rochester. Patient medical information, as well as documentation of symptoms, were gleaned from medical charts. Questionnaires were sent to patients regarding their experiences.

Results:

Of the 40 patients with breast cancer who were prescribed rose geranium nasal spray, 100% were receiving cancer-directed therapy: 58 % were receiving taxane chemotherapy; others received a variety of cytotoxic and targeted therapy treatments. Twenty patients who had used the spray product returned surveys. Patient-reported nasal symptoms included bleeding (90%), dryness (86%), pain (81%), scabbing (67%) and sores (52%); patients consistently reported symptoms at a higher proportion than did healthcare providers. All patients who used the rose geranium nasal spray reported symptomatic benefit; one reported a little benefit, 11 (55%) reported moderate benefit and eight (40%) reported dramatic or complete resolution of symptoms. The therapy was well tolerated in most patients.

Conclusions:

Rose geranium in sesame oil nasal spray appears to improve patient-reported nasal symptoms associated with cancer-directed therapy.

2018-06-01·International forum of allergy & rhinology1区 · 医学

Medical treatment of epistaxis in hereditary hemorrhagic telangiectasia: an evidence‐based review

1区 · 医学

Review

作者: Ryan, Matthew W. ; Reh, Douglas D. ; Clark, Christopher ; Halderman, Ashleigh A. ; Marple, Bradley F. ; Poetker, David M. ; Sindwani, Raj ; Invernizzi, Rosangela

Background:

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant hereditary disorder resulting in vascular dysplasia and formation of arteriovenous malformations. Recurrent epistaxis is a hallmark of the disease. An array of medical therapies are used in this patient population, but robust evidence‐based recommendations regarding the medical treatment of epistaxis are lacking. This systematic review was performed to look at the current literature and make meaningful evidence‐based recommendations.

Methods:

A search of the Ovid MEDLINE, Embase, and Cochrane databases was conducted by a research librarian. Abstracts in the English language and published in a peer‐review journal were reviewed for relevance and inclusion. PRISMA guidelines were followed.

Results:

Eighteen studies met the inclusion criteria. In a few small studies, thalidomide was shown to consistently improve severity and frequency of epistaxis and improve hemoglobin concentrations while decreasing the need for transfusion. Tranexamic acid appeared to only impact the epistaxis severity score and not other clinical outcomes. Selective estrogen modulators (SERMs), propranolol, rose geranium oil, and N‐acetylcysteine, have demonstrated promising efficacy in small trials.

Conclusion:

Appropriate medical therapies for epistaxis outcomes in HHT remain undefined, and there is no “gold standard.” Many of the studies are small and the data reported are heterogeneous, and therefore the ability to make strong evidence‐based recommendations is limited. However, many different medications appear to be promising options.

2013-04-01·The Laryngoscope1区 · 医学

Efficacy of a topical sesame/rose geranium oil compound in patients with hereditary hemorrhagic telangiectasia associated epistaxis

1区 · 医学

Article

作者: Douglas D. Reh ; Kevin Hur ; Christian A. Merlo

Abstract:

Objectives/Hypothesis::

Topical Sesame/Rose geranium oil compound is an effective therapy for hereditary hemorrhagic telangiectasia (HHT) associated epistaxis.

Study Design::

Cohort Study.

Methods::

Twenty patients with HHT confirmed by the Curaçao criteria were treated with a sesame/rose geranium oil topical compound between January 2010 and June 2011. A treatment evaluation survey was conducted at least 3 months after treatment initiation. Changes in epistaxis severity scores (ESS), patient satisfaction, and any adverse effects were assessed.

Results::

A total of 20 patients completed the study. The average (SD) age was 54.4 (14.6), and 14 (70%) were female. The median time on rose geranium oil was 183 days (IQR: 114–311). At the conclusion of the study, 18 (90%) were still using rose geranium oil. The majority (75%) of patients subjectively felt improvement with the treatment. The improvement was felt to be gradual in 25% and immediate in 50% of patients. Mean (SD) overall satisfaction using a 10‐point Likert scale was 7.8 (3.1), with 50% of the patients reporting a satisfaction rating of 10. Mean (SD) epistaxis severity score (ESS) prior to treatment was 5.3 (1.7). After treatment with sesame/rose geranium oil, mean (SD) ESS was found to be 3.5 (1.8). Treatment with sesame/rose geranium oil was associated with a statistically significant improvement in ESS by 1.81 (P <0.0001). There were no adverse side‐effects from the treatment.

Conclusion::

A sesame/rose geranium oil compound can significantly reduce the epistaxis severity scores of patients with hereditary hemorrhagic telangiectasia‐related epistaxis.

项与玫瑰和天竺葵提取物相关的新闻（医药）

2023-01-18

·PRNewswire

Worldwide Essential Oils Industry to 2027 - Increase in Demand for Aromatherapy Drives Growth

DUBLIN, Jan. 18, 2023 /PRNewswire/ -- The "Essential Oils Market By Product Type, Application (Food & beverages, Cosmetics & Toiletries, Aromatherapy, Home Care, and Health Care), Source (Fruits & Vegetables, Herbs & Spices, Flowers), Method of Extraction and Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering. The global essential oils market size is estimated to be valued at USD 8.8 billion in 2022 and is projected to reach USD 15.3 billion by 2027, recording a CAGR of 11.8% in terms of value. By application, the aromatherapy is projected to grow rapidly during the forecast period The rising popularity of aromatherapy and other alternative medicine is increasing in demand, as are the relaxing effects of essential oils when applied through a massage. The health industry has begun to incorporate essential oils in aromatherapy applications to treat Alzheimer's, bronchitis, and various cardiovascular problems. Changing lifestyles and their consequences, such as high stress and depression, along with increasing disposable incomes, results in an increase in demand for aromatherapy. Ginger oil, pine oil, oregano oil, and wintergreen oil are some of the essential oils used on a large scale in alternative therapies. The National Association for Holistic Aromatherapy (NAHA), the Alliance of International Aroma Therapists, and The Canadian Federation of Aroma Therapists have established standards for aromatherapy certification in the US and Canada. This would allow the essential oil industry to use different oils for various aromatherapy products, globally. By type, the orange essential oil is widely used in all the domains due to the presence of the high amount of vitamin C and appealing fragrance Oranges are full of vitamin C and offer several health advantages. The rind of the sweet orange, Citrus sinensis, is used to make orange essential oil. Cold pressing, a technique used to extract the oils from the rind, is used to accomplish this. Brazil is the leading orange producer in the world producing about 30% of the world's output. Orange oil, which is energetic, is one of the most widely used options in aromatherapy. The oil can decrease various kinds of pain such as inflammation, muscle spasms, tissue damage, pain from bone fractures, headache, etc. The Asia Pacific market is being driven by an increase in demand for domestic products brought on by an expanding middle class The Asia Pacific region is mostly segmented into India, China, Japan, New Zealand, Australia, and Rest of Asia pacific. The improving standard of living and high per capita income in the region, along with higher expenditure, are driving up the demand for essential oils, which has been significantly influenced by the growth of the wellness and leisure sectors. The demand for citrus-based essential oils like orange and lemon has also attracted a lot of consumer interest in some of nations. The product is becoming more widely used in the personal care and household products sectors, and the usage of citrus essential oil in tastes, odorants, and pharmaceutical substances has lately increased. With emerging economies, growing industrialization, increasing demand for processed foods, and consumer preference for quality products, ingredient suppliers are becoming increasingly optimistic about the growth of the food & beverage industry. Key Topics Covered: 1 Introduction 2 Research Methodology 3 Executive Summary 4 Premium Insights 4.1 Attractive Opportunities for Players in Essential Oil Market 4.2 Essential Oils Market: Major Regional Submarkets 4.3 Asia-Pacific: Essential Oil Market, by Source & Country 4.4 Asia-Pacific: Essential Oil Market, by Application 4.5 Essential Oil Market, by Methods of Extraction 4.6 Essential Oil Market, by Application & Region 5 Market Overview 5.1 Introduction 5.2 Macroeconomic Indicators 5.2.1 Rise in Depression and Anxiety Disorders 5.2.2 Increasing Demand for Organic Food 5.3 Market Dynamics 5.3.1 Drivers 5.3.1.1 Increase in Demand for Aromatherapy 5.3.1.2 Increasing Demand for Natural Ingredients and Clean Label Products 5.3.1.3 Increased Use of Essential Oils in Homecare Products 5.3.1.4 Use of Essential Oils as an Additive in Feed 5.3.1.5 Demand for Essential Oils in Cosmetic & Fragrance Industry 5.3.2 Restraints 5.3.2.1 Depletion of Natural Resources 5.3.2.2 Side Effects Associated with Specific Essential Oils 5.3.3 Opportunities 5.3.3.1 Powdered Essential Oil to Create New Opportunities 5.3.4 Challenges 5.3.4.1 Prevalence of Synthetic/Adulterated Products 6 Industry Trends 6.1 Introduction 6.2 Value Chain 6.2.1 Research and Product Development 6.2.2 Raw Material Sourcing 6.2.3 Production 6.2.4 Packaging, Storage, and Distribution 6.2.5 End-Users 6.3 Supply Chain Analysis 6.4 Market Map and Ecosystem of Essential Oils Market 6.4.1 Demand Side 6.4.2 Supply Side 6.4.3 Ecosystem Map 6.5 Trends/Disruptions Impacting Customers' Businesses 6.5.1 Revenue Shift and New Revenue Pockets in Essential Oil Market 6.6 Technology Analysis 6.6.1 Ultrasonic Hydro Distillation 6.6.2 Pressurized Hot Water Extraction 6.6.3 Drying Technology 6.6.4 Encapsulation 6.7 Pricing Analysis 6.7.1 Selling Prices Charged by Key Players in Terms of Application 6.8 Essential Oils Market: Patent Analysis 6.8.1 List of Major Patents 6.9 Trade Analysis: Essential Oil Market 6.9.1 Export Scenario: Essential Oils for Citrus Fruits 6.9.2 Import Scenario: Citrus Fruit Essential Oils 6.9.3 Export Scenario: Essential Oils 6.9.4 Import Scenario: Essential Oils 6.10 Case Studies: Essential Oil Market 6.10.1 Rocky Mountain Oils: Sustainable Packaging 6.10.2 Doterra: Increase Operations Efficiency 6.11 Key Conferences and Events, 2022-2023 6.12 Tariff and Regulatory Landscape 6.12.1 Regulatory Bodies, Government Agencies, and Other Organizations 6.13 Porter's Five Forces Analysis 6.14 Key Stakeholders and Buying Criteria 7 Essential Oils Market, by Type 7.1 Introduction 7.2 Orange Oil 7.2.1 Increased Use in Aromatherapy 7.3 Peppermint Oil 7.3.1 Europe and Asia-Pacific to Have Significant Impact on Market 7.4 Lemon Oil 7.4.1 Rise in Demand for Nutraceuticals with Natural Flavor 7.5 Lavender Oil 7.5.1 Improves Skin Health 7.6 Lime Oil 7.6.1 Effective for Skin Infection Treatments 7.7 Rosemary Oil 7.7.1 Increased Usage in Healthcare Products due to Antioxidant Properties 7.8 Cornmint Oil 7.8.1 Powerful Antibacterial and Antiseptic Oil 7.9 Spearmint Oil 7.9.1 Extensively Used in Food & Beverage Industry as Flavoring Ingredient 7.10 Geranium Oil 7.10.1 Primary Floral Component in Fragrance and Cosmetics 7.11 Clove Leaf Oil 7.11.1 Used for Oral Health due to Germicidal Properties 7.12 Rose Oil 7.12.1 Widely Used in Aromatherapy 7.13 Coriander Oil 7.13.1 Use in Seasonings due to Flavoring Properties 7.14 Tea Tree Oil 7.14.1 Therapeutic Benefits to Increase Demand in Skincare and Cosmetics Industry 7.15 Citronella Oil 7.15.1 Large-Scale Use in Aromatherapy to Treat Migraine and Headaches 7.16 Eucalyptus Oil 7.16.1 High Demand in Dental Care due to Germicidal Properties 7.17 Jasmine Oil 7.17.1 Extensively Used for Health Benefits 7.18 Other Types 8 Essential Oils Market, by Method of Extraction 8.1 Introduction 8.2 Distillation 8.2.1 Steam Distillation Method Used Extensively to Obtain Essential Oils Economically 8.3 Cold Press Extraction 8.3.1 Citrus Fruits Extracted Via Cold Press 8.4 Carbon Dioxide Extraction 8.4.1 Aroma and Bioactive Components of Essential Oils Effectively Retained 8.5 Other Extractions 9 Essential Oils Market, by Source 9.1 Introduction 9.2 Fruits & Vegetables 9.2.1 Cold Press Method Preferred for Essential Oil Extraction from Fruits and Vegetable 9.3 Flowers 9.3.1 Essential Oils Represent an Upstream Business Opportunity for Floriculture Market 9.4 Herbs & Spices 9.4.1 Herb-Derived Essential Oils as Natural Replacers of Compounds of Synthetic Origin 10 Essential Oils Market, by Application 10.1 Introduction 10.2 Food & Beverages 10.2.1 Extensive Use of Citrus Essential Oils in Food & Beverage Industry 10.3 Cosmetics & Toiletries 10.3.1 Extensive Use of Essential Oils due to Fragrance and Functional Properties 10.4 Aromatherapy 10.4.1 Therapeutic Potential of Essential Oils 10.5 Homecare 10.5.1 Demand for Natural Ingredients to Boost Demand 10.6 Healthcare 10.6.1 Mental Well-Being to Drive Healthcare Industry 10.7 Other Applications 11 Essential Oils Market, by Region 12 Competitive Landscape 12.1 Overview 12.2 Market Share Analysis, 2021 12.3 Segmental Revenue Analysis of Key Players 12.4 Key Player Strategies 12.5 Company Evaluation Quadrant (Key Players) 12.5.1 Stars 12.5.2 Emerging Leaders 12.5.3 Pervasive Players 12.5.4 Participants 12.5.5 Product Footprint 12.6 Essential Oils Market, Evaluation Quadrant for Start-Ups/Smes, 2021 12.6.1 Progressive Companies 12.6.2 Starting Blocks 12.6.3 Responsive Companies 12.6.4 Dynamic Companies 12.6.5 Competitive Benchmarking of Key Start-Ups/Smes 12.7 Competitive Scenario 12.7.1 New Product Launches 12.7.2 Deals 12.7.3 Others 13 Company Profiles 13.1 Introduction 13.2 Key Player 13.2.1 Dsm 13.2.2 Givaudan 13.2.3 International Flavors & Fragrances Inc. (Iff) 13.2.4 Sensient Technologies Corporation 13.2.5 Cargill, Incorporated 13.2.6 Symrise 13.2.7 Robertet, Sa 13.2.8 Mane 13.2.9 Doterra 13.2.10 Now Foods 13.2.11 Synthite Industries Ltd. 13.2.12 Lebermuth, Inc. 13.2.13 Biolandes 13.2.14 Norex Flavours Private Limited 13.2.15 India Essential Oils 13.3 Other Players (Smes/Start-Ups) 13.3.1 Falcon 13.3.2 Farotti S.R.L. 13.3.3 Vidya Herbs 13.3.4 Young Living Essential Oils, Lc. 13.3.5 Essential Oils of New Zealand Ltd. 13.3.6 Veda Oils 13.3.7 Hcp Wellness 13.3.8 Vital Herbs 13.3.9 Cv Rasayana Wangi 13.3.10 Alchemy Chemicals 14 Adjacent & Related Markets 15 Appendix For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

100 项与玫瑰和天竺葵提取物相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
鼻腔感染	临床3期	美国	National Cancer Institute	2020-11-13

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04620369 (Pubmed)	临床3期	鼻部疾病	-	Rose geranium in sesame oil (RG) nasal spray	憲壓繭襯廠鑰簾築醖觸(鹹構衊夢襯窪淵餘簾製) = 膚築糧艱衊壓壓艱選繭獵鏇願鏇獵齋膚醖願憲 (製遞繭餘齋鬱獵範簾壓 )	积极	2024-05-24
				Isotonic saline (IS) nasal spray	憲壓繭襯廠鑰簾築醖觸(鹹構衊夢襯窪淵餘簾製) = 積觸壓鏇淵餘鬱淵範積獵鏇願鏇獵齋膚醖願憲 (製遞繭餘齋鬱獵範簾壓 )
NCT04620369 (ASCO2023)	临床3期	鼻部疾病	106	Rose geranium in sesame oil nasal spray	繭齋襯淵選膚觸糧觸廠(鹽淵蓋網鹽繭襯獵積齋) = 鬱淵淵窪蓋築選顧遞獵構艱鏇淵構夢築遞積願 (憲蓋廠壓鬱繭網繭選襯 )	积极	2023-05-31
				Isotonic saline nasal spray	繭齋襯淵選膚觸糧觸廠(鹽淵蓋網鹽繭襯獵積齋) = 積餘廠網鏇壓鏇製膚憲構艱鏇淵構夢築遞積願 (憲蓋廠壓鬱繭網繭選襯 )