Moya-Moya Disease

近日，同济医院成为中国干细胞与再生医学协同创新平台成员单位，并获授牌华中干细胞库，填补了华中地区无干细胞库的空白。 近日，同济医院成为中国干细胞与再生医学协同创新平台成员单位，并获授牌华中干细胞库，填补了华中地区无干细胞库的空白。 科研团队进行研究 干细胞是一种具有自我复制和多向分化潜能的细胞，其研究和应用一直是科学研究的热点领域。干细胞与再生医学是新兴生物技术的前沿领域，不仅是揭示生命奥秘的一把重要“钥匙”，也在重症免疫缺陷、神经退行性疾病等疾病的治疗，组织器官的培养和移植，新药的研发和筛选等方面具有重要的价值和意义。 同济医院康复医学科主任、华中干细胞库负责人陈红教授介绍，为了能将干细胞尽量运用到临床医疗实践中，规范干细胞的来源，保证干细胞的标准化制备和全流程检测是关键。因此，建立标准、规范的干细胞资源库至关重要。同济医院从2018年起开始进行胚胎干细胞来源的功能干细胞的相关临床研究工作，在干细胞临床研究数量和质量上均处于华中地区领先水平。 科研团队进行研究 据悉，华中干细胞库主要致力于人胚干细胞和人多能干细胞的制备、干细胞药物的开发和干细胞库的建立。为难治性疾病如脊髓损伤、脑外伤、早衰等提供再生医学新疗法，并围绕干细胞与再生医学开展科研工作，重点建设正常人和患者的多能干细胞库及工作库，干细胞临床前基础研究及转化研究等技术平台。目前平台已有可诱导多能干细胞50余株，罕见病（运动神经元病、家族型烟雾病等）40株，并积极开展相关的备案临床研究及罕见病药物筛选研究。

MONDAY, July 17, 2023 (American Heart Association News) -- At 32, Allison Graff saw her life as a treasure. She loved her job in Florida. She owned her own home. She discovered the delights of dancing, which she did at clubs as often as possible. Working up a sweat and getting all tired out just seemed to be the price she paid for having fun. But when the sweating continued long past leaving the dance floor, and when even taking a shower totally wiped her out, she knew something was wrong. A visit to the emergency room confirmed her fears. And while that trip to the ER in 2008 started an often-exhausting journey of high hopes and devastating despair, she still considers what she did that fateful day "the best decision I could have made." An angiogram showed no blockage. Good news, of course. However, an electrocardiogram showed the electrical system of her heart wasn't working correctly. We can put our time and energy into figuring out why it happened, the cardiologist told her, or we can spend our time and energy getting you better. Graff opted for the latter. She moved back home to West Monroe, New York, where her parents helped her develop and maintain healthy habits. She started taking prescription medications, stopped smoking and cut sodium from her diet. She and her father went on long walks together. Eventually, she got stronger. "Family love is powerful medicine," Graff said. "When you're recuperating and surrounded by people helping you do the right things, that allows you to take a step back and say, 'Hmm, what's best for me now?'" She took a part-time, low-stress job, then later began working full time in the arts world, which she loved. She kept getting better. She married and in 2013 had a baby, a daughter she named Avery. "My heart had really responded to the medication and the new understanding that life wasn't about how much I could do in a day," she said. "I was focusing on my family and on my health. I practiced yoga. I did a lot of good things for my body." Then in 2016, her father died. He had been battling amyotrophic lateral sclerosis, also called Lou Gehrig's disease. Graff had helped her mother and sister care for him, which was a labor of love, but also tremendously stressful. Her health began to decline again and her marriage took a downturn. She and her husband separated in 2019, and Graff and Avery moved in with her mother. Graff started smoking again. Stress engulfed her. In 2020, a day after her divorce was finalized, Graff stood up while visiting with a friend and passed out. At the ER, she was diagnosed with atrial fibrillation . Doctors implanted a loop recorder to monitor her heart. She was sent home and told to take it easy. She tried. But she developed heart palpitations , became depressed, lost her appetite – and didn't know what to do. Then she had a mini- stroke . "I felt my lip go numb," Graff said. "When I reached out to touch my face, I had no control over my arm." Tests at the hospital confirmed mini-strokes in four areas of her brain. Additionally, she was diagnosed with moyamoya disease, a constriction of blood vessels feeding the brain. If one of those vessels were to pop, she'd have a hemorrhagic stroke. For someone with atrial fibrillation, strokes and mini-strokes are "quite common," said Jeffrey Ascenzo, Graff's cardiologist. "This is especially true when the arrhythmia occurs only intermittently and sometimes without any other symptoms," he said. "The underlying stroke risk is why atrial fibrillation is such a dangerous arrhythmia." It's also the most common arrhythmia, he said, but not so much in a woman Graff's age. Nor is another of her diagnoses: cardiomyopathy. Graff couldn't do anything about why she developed these conditions. She could, though, have brain surgery to correct moyamoya disease. So, a year ago – after focusing on reducing stress, creating a stable life for herself and Avery, and adopting a make-lemonade-out-of-lemons mantra – she did. Graff may need additional surgeries in the future. But for now, she's focusing on living life to the fullest, moment by moment. That includes teaching yoga, identifying her feelings, listening to her body, and saying no when she needs to say no. "She's staying active, eating right and, especially, staying compliant with her medications and regular follow-up visits," Ascenzo said. "I see no reason why she cannot live out and fulfill a normal life span." Graff said her emotions are more constant these days. And while she may not be dancing the nights away as she was before her heart issues began, she has found another source of joy. "I'm doing handstands," she said. "Before all this, I was too scared to try." American Heart Association News covers heart and brain health. Not all views expressed in this story reflect the official position of the American Heart Association. Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved. By Leslie Barker, American Heart Association News Posted July 2023

CHICAGO, May 4, 2023 /PRNewswire/ -- The neurovascular devices industry is expected to experience significant growth in the near future, driven by increasing demand for these devices to treat neurological disorders such as stroke, brain aneurysms, and AVMs. Advancements in technology, such as the development of more precise and less invasive devices, are also expected to drive growth. Additionally, the industry is attracting significant investments, leading to the development of new and innovative products. The market is expanding geographically, with increasing demand in developing countries, providing additional growth opportunities. However, challenges such as high costs associated with these devices and the need for skilled healthcare professionals to operate them may impede growth. Overall, the neurovascular devices industry is poised for growth in the near future, as advancements in technology and increasing demand for neurological treatments drive market expansion. Neurovascular Devices Market in terms of revenue was estimated to be worth $3.6 billion in 2023 and is poised to reach $5.5 billion by 2028, growing at a CAGR of 8.7% from 2023 to 2028 according to a new report by MarketsandMarkets™. The neurovascular devices market is mainly driven by rising incidence of neurovascular diseases, availability of medical reimbursements for neurovascular procedures, expansion of healthcare infrastructure across emerging economies, increased focus of players on boosting the research in novel neurovascular devices, and growing demand for minimally invasive surgical procedures. Download an Illustrative overview: Browse in-depth TOC on "Neurovascular Devices Market" 223 - Tables 37 - Figures 263 - Pages Neurovascular Devices Market Scope: However, shortage of skilled neurosurgeons and high procedural cost of neurovascular, stringent regulatory approval process are some of the key challenge faced by the leading players in the global neurovascular devices market. Cerebral Aneurysms Segment is expected to account for the largest neurovascular devices market share in 2022, by disease pathology Based on disease pathology, the neurovascular devices market is segmented into cerebral aneurysm, ischemic strokes, carotid artery stenosis, arteriovenous malformations & fistulas, and other disease pathologies (includes cavernous malformations and moyamoya disease). The cerebral aneurysm segment is anticipated to hold the largest market share of neurovascular devices market. The increasing market demand for neurovascular devices for aneurysm treatment can be attributed mainly to the presence of neuro-interventional devices for cerebral aneurysm such as embolic coils, increase in the technological advancement in the neurovascular devices, and rise in the cases of cerebral aneurysm globally. The ambulatory care centers segment is anticipated to register highest CAGR during the forecast period. Based on end user, the neurovascular devices market is segmented into hospitals & surgical centers, ambulatory care centers, and research laboratories and academic institutes. The ambulatory care centers segment is projected to register the highest CAGR during the forecast period. Rising number of ambulatory surgery centers across developed countries, along with the ease of scheduling, the focused clinical staff, the improved productivity and the increased safety, and efficacy of these centers, and growing preference of minimally invasive surgical processes are the major factors that are expected to drive the growth of ambulatory care centers segment in the coming years. North America to dominate the global neurovascular devices market Based on the region, the neurovascular devices market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa. North America accounted for the largest share of neurovascular devices market. The large share of North America can be attributed to the high adoption of neurovascular devices in the region, the strong presence of device manufacturers, and the availability of significant R&D investments for product development. Asia Pacific is expected to grow at the highest CAGR during the forecast period owing to the presence of a large target patient population, rising awareness on the advantages of minimally invasive neurosurgical processes., geographical expansion of players in region, and government initiatives to modernize & expand healthcare infrastructure. Inquiry Before Buying: Neurovascular Devices Market Dynamics: Drivers: Rising incidence of neurovascular diseases Availability of medical reimbursements for neurovascular procedures Expansion of healthcare infrastructure across emerging economies Rising demand for effective neurovascular therapies Restraints: Shortage of skilled neurosurgeons High procedural cost of neurovascular surgeries and associated products Opportunities: Rising R&D activities for neurovascular therapies Growing preference for minimally invasive neurosurgical procedures Challenges: Stringent regulatory approval process for medical devices Key Market Players: Major players in neurovascular devices market include Stryker (US), Johnson & Johnson (US), Medtronic plc (US), Terumo Corporation (Japan), and Penumbra, Inc. (US). Get 10% Free Customization on this Report: Recent Developments: In December 2022, Stryker (US) established a new research & development facility at International Park, Gurgaon, India, intending to accelerate innovations in neurovascular devices for stroke treatment In February 2022, Johnson & Johnson (US) launched the EMBOGUARD, a balloon guide catheter for treating acute ischemic stroke. In January 2021, Penumbra, Inc. (US) and Genesis Medtech (Australia) collaborated to expand Penumbra's market capabilities in China by commercializing and producing novel neurovascular products in China. Neurovascular Devices Market Advantages: Improved patient outcomes: Neurovascular devices are designed to diagnose and treat various neurological disorders such as aneurysms, stroke, and arteriovenous malformations (AVMs). These devices have shown to improve patient outcomes by reducing the incidence of complications, minimizing the risk of bleeding, and improving patient recovery time. Increased demand: The increasing prevalence of neurological disorders such as stroke, brain aneurysms, and AVMs has led to a growing demand for neurovascular devices. This trend is expected to continue as the population ages and the incidence of these disorders increases. Technological advancements: Neurovascular devices are undergoing continuous technological advancements, resulting in improved safety, efficacy, and ease of use. These advancements have led to the development of devices that are more precise, durable, and less invasive, resulting in better patient outcomes. Growing investments: The neurovascular devices market has attracted significant investments in recent years due to its potential for growth and profitability. This investment has resulted in the development of new and innovative products, as well as increased research and development activities. Market expansion: The neurovascular devices market is expanding geographically, with increasing demand for these devices in developing countries. This expansion is expected to provide significant growth opportunities for the market in the coming years. Neurovascular Devices Market - Report Highlights: Recession Impact Analysis: The existing report includes an analysis of the impact of recession on the market overview section. Newer and improved representation of financial information: The new edition of the report provides updated financial information till 2022-2023 (depending on the availability) for each listed company in a graphical representation in a single diagram (instead of multiple tables). This will allow for the easy analysis of the present status of profiled companies in terms of their financial strength, profitability, key revenue-generating country/region, and business segment focus in terms of the highest revenue-generating segment. Recent Market Developments: Recent developments are helpful to know the market trend and growth strategies adopted by players in the market. The report provides the updated developments in terms of acquisitions, agreements, expansions, and agreements/collaboration etc. Latest Product portfolio: The new edition of the report provides an updated product portfolio of the companies profiled in the report. Competitive leadership mapping: The competitive landscape chapter has been updated with the market evaluation matrix. The competitive landscape also includes the market share analysis for 2023, updated competitive leadership mapping, and competitive situation & trends. This report version has added the vendor dive matrix, covering a comprehensive study of the key vendors. Competitive leadership mapping has also been done for start-ups/SMEs. Related Reports: Interventional Cardiology Devices Market - Global Forecasts to 2027 Neuromodulation Market - Global Forecasts to 2027 Microcatheters Market - Global Forecasts to 2027 Peripheral Vascular Devices Market - Global Forecasts to 2026 Ambulatory Surgical Centers Market - Global Forecasts to 2025 About MarketsandMarkets™: MarketsandMarkets™ is a blue ocean alternative in growth consulting and program management, leveraging a man-machine offering to drive supernormal growth for progressive organizations in the B2B space. We have the widest lens on emerging technologies, making us proficient in co-creating supernormal growth for clients. The B2B economy is witnessing the emergence of $25 trillion of new revenue streams that are substituting existing revenue streams in this decade alone. 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