Pancreatic Carcinoma, Familial

Live moderated video webcast on Thursday, July 13th at 2:00 PM ETBERWYN, Pa., July 05, 2023 (GLOBE NEWSWIRE) -- Panavance Therapeutics Inc. (“Panavance” or the “Company”), a clinical-stage pharmaceutical company advancing the development of a novel oncology therapeutic intended to improve the effectiveness of cancer treatments and quality of life for the patients that receive them, today announced that Greg Bosch, Chairman and CEO, James Costin, M.D., Head of Research & Development, José Iglesias, M.D., Chief Medical Officer, and Ben Steinmetz, Chief Commercial Officer of Panavance Therapeutics will participate in the Virtual Investor Summer Spotlight Series on Thursday, July 13, 2023 at 2:00 PM ET. A live video webcast of the presentation will be available in the Events section of the Resources page on the Company’s website (www.panavance.com). A webcast replay will be available two hours following the live presentation and will be accessible for 90 days. About Panavance Therapeutics Panavance Therapeutics Inc. is a privately-held, clinical-stage pharmaceutical company developing a novel oncology platform focused on improving the outcomes and quality of life for cancer patients. Panavance, a US Delaware company, is located in Berwyn, PA. It was founded in 2021 and is a subsidiary of Swiss privately held Ed. Geistlich Söhne AG für Chemische Industrie. Panavance’s lead program, misetionamide (also known as GP-2250), is a tumor cell selective and broadly active small molecule with a unique dual mechanism of action of selectively disrupting the energy metabolism of cancer cells leading to cancer cell death as well as impacting nuclear factor-κB (“NFκB”) which effects cancer cells’ ability for protein synthesis and DNA transcription thereby restricting cancer cell growth and proliferation. The Company is advancing towards the initiation of two registration directed clinical studies expected to start in 2024: a Phase 2/3 study of GP-2250 for the treatment of ovarian cancer and a pivotal Phase 3 clinical trial as a first-line maintenance therapy for non-BRCA mutated pancreatic cancer patients, a population for which there are no FDA approved agents. GP-2250’s unique mechanism of action and extensive preclinical data supports broad oncology utility with the potential to be effective in additional indications, including melanoma, squamous cell, breast and colorectal cancers.For more information, please visit panavance.com and connect with the Company on Twitter and LinkedIn. References and links to websites have been provided for convenience, and the information contained on any such website is not a part of, or incorporated by reference into, this press release. Panavance is not responsible for the contents of third-party websites. Investor Relations Contact JTC Team, LLC Jenene Thomas 833-475-8247 panavance@jtcir.com

STAMFORD, Conn., Feb. 28, 2023 (GLOBE NEWSWIRE) -- GeneDx (Nasdaq: WGS), a leader in delivering improved health outcomes through genomic and clinical insights, today announced its contributions to eight posters, one platform presentation and one symposium session to be released at the upcoming 2023 American College of Medical Genetics and Genomics (ACMG) Annual Clinical Genetics Meeting. The announcement coincides with Rare Disease Day and is just the latest example of the company’s dedication to eradicating the multi-year diagnostic odyssey faced by many families seeking clinical diagnoses for critically ill patients. GeneDx is a leader in rare disease diagnosis and has spent the last 20 years building one of the largest rare disease datasets in the genomics industry, including data from more than 400,000 clinical exomes. These data play a critical role in the company’s research -- and in the insights it delivers to providers -- to enable the delivery of informed, patient-centered care. It also supports the identification, discovery and development of creating therapeutics to manage and treat rare genetic diseases. “While today is officially recognized as Rare Disease Day, every day is rare disease day for us as we work tirelessly to shorten and ultimately end the diagnostic odyssey,” said Katherine Stueland, GeneDx President and CEO. “With the increasing focus on patients with rare disease, we’re proud to bolster the medical community’s ability to diagnose disease more accurately and rapidly. Our research contributions are evidence of our investment into unlocking and advancing the power of genomic information to become the standard of care in diagnosing and treating rare disease.” The research and collaborations being shown at ACMG are just the latest demonstration of the company’s continued success in leveraging genetic data and technology to generate clinical insights that lead to improved and faster diagnoses, new and better patient treatments and improved outcomes. GeneDx’s presence at ACMG on March 15 at the Salt Palace Convention Center in Salt Lake City, Utah, is as follows: ORAL PRESENTATION RESEARCH COLLABORATIONS Genomic Uniform-screening Against Rare Diseases in All Newborns (GUARDIAN): Presented by Dr. Wendy Chung, MD, PhD, Overall Study Principal Investigator, Columbia University: [Part of the R. Rodney Howell Symposium, March 15, 2023, 10:45 AM MT] Developing a Framework for Sequence Variant Interpretation for Multiple X-linked Inborn Errors of Metabolism: The ClinGen IEM Working Group Experience In partnership with ClinGen [March 17, 2023 3:30 PM MT] GENEDX POSTER PRESENTATION RESEARCH COLLABORATIONS In collaboration with Tara Wenger and Alexandra Keefe of University of Washington: Parental Perspectives on SeqFirst Neonatal Rapid Genome Sequencing SeqFirst: Impact of a Precise Genetic Diagnosis on End-of-Life Decision Making in the NICU POSTER PRESENTATIONS SHOWCASING STUDIES LED BY GENEDX Diagnostic Yield of Copy Number Variants by Exome Sequencing versus Chromosomal Microarray Four Cases of Mosiac Triploidy Identified by Trio Exome Sequencing POSTER PRESENTATION RESEARCH COLLABORATIONS: RARE DISEASE DISCOVERY AND CONTRIBUTIONS TO PROFESSIONAL DECISION-MAKING BODIES Rare Disease Discovery: De novo missense variants in ZBTB47 cause a neurodevelopmental phenotype of developmental delays, seizures, and possible movement abnormalities Mutation of Cohesin Release Factors WAPL, PDS5A, and PDS5B Defines a New Class of Cohesinopathies Professional Decision-Making Bodies: ATM and PALB2 Variant Curation Guidelines Progress Update: ClinGen Hereditary Breast, Ovarian, and Pancreatic Cancer Variant Curation Expert Panel In partnership with ClinGen The ClinGen ENIGMA BRCA1/2 Expert Panel: a dynamic framework for evidence-based recommendations to improve classification criteria for variants in BRCA1/2 In partnership with ClinGen About GeneDx GeneDx delivers personalized and actionable health insights to inform diagnosis, direct treatment and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation, fueled by one of the world’s largest rare disease data sets. For more information, please visit genedx.com and connect with us on LinkedIn, Facebook, and Instagram. Media contact Stephanie Kahan Press@genedx.com Investor contact Tricia Truehart Investors@genedx.com

The first blood test dedicated to the early detection of pancreatic ductal adenocarcinoma in individuals at high-risk for familial or hereditary pancreatic cancer. MARLBOROUGH, Mass.--(BUSINESS WIRE)-- Today, Immunovia Inc., the American subsidiary of Immunovia AB (Nasdaq Stockholm: IMMNOV), announced that it has received final approval to begin patient testing for the IMMray® PanCan-d test – the first blood test on the market dedicated to the early detection of pancreatic cancer. This approval was received from the Massachusetts Department of Public Health on August 3, 2021. Immunovia, Inc. received its CLIA Certificate of Registration on June 21, 2021 (CLIA Number: 22D2227265). “We are extremely pleased to have achieved this important milestone and to be able to launch the first non-invasive, highly accurate blood test that can help detect pancreatic cancer in early stages. The IMMray® PanCan-d test fulfills an unmet clinical need and our ambition is to make the test available to individuals in all the high-risk groups for pancreatic cancer. As a first step, we will launch the test for the familial/hereditary high-risk group,” said Patrik Dahlen, Immunovia’s CEO. There will be approximately 60,000 new pancreatic cancer cases in the U.S. this year. Approximately 10-15% of all pancreatic cancer cases are attributed to a familial or hereditary link. “The early diagnosis of pancreatic cancer is key to improving patient outcomes and survival rates. We’re encouraged by the results presented by Immunovia’s IMMray® PanCan-d blood test and the company’s progress toward an early detection strategy for this disease,” said Julie Fleshman, President and CEO of the Pancreatic Cancer Action Network (PanCAN). The IMMray® PanCan-d test is the first product developed from Immunovia’s proprietary immunoproteomics-based technology platform, IMMray®, that measures the immune system’s response to diseases in the blood. In a validation study presented in March, early stage (stages I and II) pancreatic ductal adenocarcinomas were detected with 99% specificity and 89% sensitivity in familial/hereditary risk group cohorts. “As someone with family history of pancreatic cancer, I understand firsthand how important it is to have a test such as this available,” said Thomas King, MD, PhD, Medical Director of Immunovia, Inc. “With the Massachusetts State approval, we are excited to be able to offer the first commercial testing option for those individuals at high-risk for pancreatic cancer.” The IMMray® PanCan-d test will be available exclusively from Immunovia, Inc., in Marlborough, MA and is intended only for individuals who are at high-risk for developing familial or hereditary pancreatic cancer. To learn more about the IMMray® PanCan-d test and familial/hereditary risk factors for pancreatic cancer, please visit: About Immunovia Immunovia AB is a diagnostic company that is developing and commercializing highly accurate blood tests for the early detection of cancer and autoimmune diseases based on Immunovia’s proprietary test platform called IMMray®. Tests are based on antibody biomarker microarray analysis using advanced machine-learning and bioinformatics to single-out a set of relevant biomarkers that indicate a certain disease. Thus, forming a unique “disease biomarker signature”. The company was founded in 2007, based on cancer studies and ground-breaking research in the Department of Immunotechnology at Lund University and CREATE Health Cancer Center, Sweden. In 2017, Immunovia, Inc. was established in Marlborough, Massachusetts, USA. The IMMray® PanCan-d test, the first blood-based test dedicated to the early detection of pancreatic cancer on the market, is offered as a laboratory developed test (LDT) exclusively through Immunovia, Inc. For more information visit: . The IMMray® PanCan-d test is undergoing clinical evaluation in some of the world’s largest clinical studies for high risk groups in pancreatic cancer, including PanFAM-1, PanSYM-1 and PanDIA-1. Immunovia’s shares (IMMNOV) are listed on Nasdaq Stockholm. For more information about Immunovia AB, please visit .