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更新于：2025-05-07

Azoospermia, Nonobstructive

非梗阻性无精子症

更新于：2025-05-07

基本信息

别名

Azoospermia, Nonobstructive、Azoospermia, nonobstructive、Nonobstructive azoospermia

+ [1]

简介-

关联

项与非梗阻性无精子症相关的药物

MediReg

靶点-

作用机制-

在研机构

Moscow State University Lomonosov

原研机构

Moscow State University Lomonosov

在研适应症

精子发生停滞 [+3]

非在研适应症-

最高研发阶段临床1/2期

首次获批国家/地区-

首次获批日期1800-01-20

项与非梗阻性无精子症相关的临床试验

NCT06941922

/ Not yet recruitingN/AIIT

Testicular Evaluation of Azoospermia Using Micro-Ultrasound

The investigation is a small feasibility study to determine whether there are imaging features related to the seminiferous tubules in the testes under microultrasound. The results from this study will provide guidance on the design and power analysis of future studies in this area.

开始日期2025-05-01

申办/合作机构

Shady Grove Reproductive Science Center PC

[+1]

NCT06706414

/ Recruiting临床1/2期IIT

Novel Treatment of Some Men With Non-Obstructive Azoospermia (NT-NOA): A Clinical Interventional Study

This clinical interventional study aims to assess whether treatment with denosumab in combination with letrozole can improve sperm production in infertile men with non-obstructive azoospermia selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker.

开始日期2025-03-01

申办/合作机构

Copenhagen University Hospital

ChiCTR2400094698

/ SuspendedN/AIIT

Research on the Function of SPDYA Gene in Spermatogenesis

开始日期2025-01-02

申办/合作机构-

100 项与非梗阻性无精子症相关的临床结果

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100 项与非梗阻性无精子症相关的转化医学

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0 项与非梗阻性无精子症相关的专利（医药）

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1,838

项与非梗阻性无精子症相关的文献（医药）

2025-12-01·Molecular Biology Reports

Whole exome sequencing reveals ABCD1 variant as a potential contributor to male infertility

Article

作者: Harmak, Houda ; Malki, Abderrahim ; Barakat, Abdelhamid ; El Hamouchi, Adil ; Charoute, Hicham ; Louanjli, Noureddine ; Redouane, Salaheddine ; Rouba, Hassan

BACKGROUNDMale infertility (MI) is a polygenic condition mainly induced by spermatogenic failure/arrest or systemic disease with a large clinical spectrum. Lately, genetic sequencing allowed the identification of several variants implicated in both aforesaid situations.METHODS AND RESULTSIn this case study, we performed whole exome sequencing (WES) on the genomic DNA of a 37-year-old Moroccan man with Non-Obstructive Azoospermia. Results revealed two variants in genes highly expressed in testicular tissue. The first was a heterozygous frameshift variant in the AURKC gene, causing a premature stop codon at position 71 of the AURKC protein, critical for spermatogenesis. The second was a hemizygous missense variant in the ABCD1 gene, resulting in an H299R substitution in the ABCD1 protein, essential for transporting Very Long Chain Fatty Acids (VLCFAs) into peroxisomes. ABCD1 variants are linked to X-linked Adrenoleukodystrophy (X-ALD), a disease caused by VLCFAs accumulation in cells. The patient's family pedigree suggests X-linked transmission of MI, which may be a subclinical form of late-onset X-ALD in affected members, indicating that the ABCD1 variant likely affects spermatogenesis. This hypothesis is supported by literature linking X-ALD to MI, ABCD1's high expression in human testes, and the significant impact of the H299R substitution on ABCD1 transporter's molecular dynamics.CONCLUSIONSThese insights highlight the role of genetic mutations in male infertility, demonstrating that spermatogenesis can be disrupted either directly by specific mutations or indirectly through broader genetic disorders, underscoring the importance of comprehensive genetic testing.

2025-05-01·Journal of Obstetrics and Gynaecology Research

Microdissection testicular sperm extraction in male partner with non‐obstructive azoospermia: Fresh or frozen–thawed sperm for intracytoplasmic sperm injection?

Article

作者: Tola, Esra Nur ; Özmen, Sevinc

AbstractAimTo compare the outcomes of intracytoplasmic sperm injection (ICSI) of fresh and cryopreserved sperm obtained via microdissection testicular sperm extraction (micro‐TESE) in cases of non‐obstructive azoospermia (NOA).MethodsA total of 147 patients with NOA who underwent micro‐TESE and obtained viable sperm via micro‐TESE at Istanbul Medipol In Vitro Fertilization unit were recruited retrospectively. The cases were divided into two groups depending on the sperm used (fresh or frozen–thawed) for ICSI: The micro‐TESE group (n = 93) underwent ICSI cycles with fresh spermatozoa and the micro‐TESE‐Thaw group (n = 54) underwent ICSI cycles with cryopreserved spermatozoa. Patient demographics, embryo development, and pregnancy outcomes were compared between the two groups.ResultsNo statistical difference was observed between the two groups in terms of demographic features (age, body mass index, etc.) and cycle characteristics (induction protocol, gonadotropin dose, etc.). Fertilization rates and embryo quality were also similar between the groups. Higher clinical pregnancy and live birth rates were observed in the micro‐TESE group than in the micro‐TESE‐Thaw group (p <0.04 and p <0.003, respectively). The miscarriage rate was higher in the micro‐TESE‐Thaw group, although the difference did not reach statistical significance.Conclusion(s)In cases where frozen sperm obtained by micro‐TESE are used, even if viable and motile sperm are found after thawing, there may be a negative impact on the ICSI result. Fresh testicular spermatozoa appear to result in better clinical pregnancy and live birth rates than cryopreserved testicular spermatozoa in males with NOA.

2025-05-01·Urology Case Reports

Non obstructive azoospermia as the only indicator of focal segmental glomerulosclerosis and chronic kidney failure: A case report

Article

作者: Sgayer, Inshirah ; Aslih, Hala ; Kaiyal, Raneen Sawaid ; Shlush, Ekaterina ; Lowenstein, Lior

Azoospermia, the absence of sperm in the ejaculate, affects 1 % of men, with non-obstructive azoospermia (NOA) comprising 60 % of cases. We report a 29-year-old male with NOA and primary infertility, initially asymptomatic with history of chronic diseases and normal evaluations. Routine blood tests revealed elevated creatinine, leading to a diagnosis of end-stage renal disease (ESRD) due to focal segmental glomerulosclerosis. After hemodialysis and kidney transplantation, semen analysis showed cryptozoospermia, suggesting partial spermatogenesis recovery. This case highlights NOA as a potential silent indicator of systemic disease, emphasizing the importance of thorough evaluation and a multidisciplinary approach in idiopathic cases.

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