预约演示

更新于：2025-05-07

Graying of Hair, Precocious

早熟性白发

更新于：2025-05-07

基本信息

别名

GRAYING OF HAIR, PRECOCIOUS、Graying of Hair, Precocious、WHITE HAIR, PREMATURE

+ [2]

简介-

关联

项与早熟性白发相关的药物

ET-03 (Eirion Therapeutics)

靶点-

作用机制-

在研机构

Eirion Therapeutics, Inc.

原研机构

Eirion Therapeutics, Inc.

在研适应症

雄激素脱发 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

项与早熟性白发相关的临床试验

NCT06552039

/ Not yet recruitingN/A

Scientific Evaluation of the Safety and Efficacy of Herbal and Non Herbal Formulations in Mitigating Hair Fall, Promoting Hair Growth, and Preventing Premature Hair Graying.

This is proof-of-science, prospective, interventional, three-arm, double-blind, randomized, safety and efficacy real world evidence study of herbal and non herbal formulations in healthy human subjects having complaint of hair fall and pre-mature graying.

开始日期2024-08-24

申办/合作机构-

ChiCTR2100047179

/ Recruiting早期临床1期IIT

The safety and efficacy of concentration growth factor partly injection in white hair

开始日期2021-06-10

申办/合作机构-

ChiCTR2000034710

/ Recruiting早期临床1期

A Randomized Controlled Clinical Study on Dumai 'Five Points' Pricking Therapy in the Treatment of Premature Hair Graying (Blood-Heat Type)

开始日期2020-07-01

申办/合作机构

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

100 项与早熟性白发相关的临床结果

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100 项与早熟性白发相关的转化医学

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0 项与早熟性白发相关的专利（医药）

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项与早熟性白发相关的文献（医药）

2024-05-16·Boletín Médico del Hospital Infantil de México

Factores pronósticos del vitiligo en la edad pediátrica

Article

作者: Anda-Ortiz, Nabil De ; Morales-Sánchez, Martha A ; Villegas-Calzada, M Fernanda ; Acatitla-Acevedo, Graciela A

BACKGROUNDVitiligo is a multifactorial disease characterized by the progressive loss of melanocytes. The worldwide prevalence ranges from 0.5% to 2%, and in children from 0% to 2.16%. The objective of this study was to determine the variables associated with progression of vitiligo.METHODSA retrospective cohort was carried out where a random sample of records of pediatric patients with vitiligo from January 2016 to December 2020 was analyzed. The variables were studied: age at onset, sex, hereditary family history, personal history of thyroid diseases, time of evolution, classification, Köebner phenomena, mucosal vitiligo, halo nevus, premature graying and the presence of other dermatoses. The final state was classified as progression, stability, partial remission and complete remission.RESULTS574 children with vitiligo; 290 (50.5%) women, 284 (49.5%) men. Non-segmental vitiligo in 324 (56.4%), segmental vitiligo in 250 (43.6%). Mean age of onset 8.7 years (SD: 4.54). Median evolution time 6 months (25^th percentile of 3 months and 75^th percentile of 24 months). Family history 27 (4.70%). Thyroid disease 7 (1.21%). Evolution remained stable in 44 (7.7%), 68 (11.8%) had progression, 32 (5.6%) complete remission, 222 (38.7%) partial remission and 208 (36.2%) one consultation. Non-segmental vitiligo was obtained p < 0.028, younger age of onset p < 0.000, and none skin comorbidities p < 0.009.CONCLUSIONSThe variables that were associated with a more progression were non-segmental vitiligo, early ages at the onset of the disease, and not presenting with other skin diseases.

2024-05-09·Cureus

Fractal Pattern in the Premature Graying of Hair: A Case Report

Article

作者: Rashid, Rashid M ; Niazi, Maryam ; Kashyap, Alisha ; Black, Troy A ; Ali, Amna M ; Phan, Brandy

Premature graying of hair (PGH) is a multifactorial condition defined by the graying of hair before the age of 20 in Caucasians and before the age of 30 in African Americans. Although the etiology remains unknown, it has been associated with genetic predisposition, oxidative stress, nutritional deficiencies, and autoimmune diseases. Current treatment options are limited but can include anti-inflammatory medications, vitamins, and hair colorants for symptom control. In this report, we present a case of premature graying in a 32-year-old male, onset at age 15, exhibiting a distinctive fractal pattern. This case represents a unique instance of PGH characterized by an unusual pattern, necessitating further investigation into potential etiological factors and underlying pathophysiological mechanisms.

2024-03-22·Cureus

Multiple Behavioral Risk Factors As Assets for Chronic Disease Prevention: Observations From Urban Primary Care Settings in Crete, Greece

Article

作者: Smyrnakis, Emmanouil ; Volkos, Panagiotis ; Mantadaki, Aikaterini E ; Linardakis, Manolis ; Petraki, Chrysi ; Nioti, Kadiani ; Stachteas, Panagiotis ; Symvoulakis, Emmanouil K ; Karelis, Andreas ; Antoniou, Aikaterini M ; Mastronikolis, Stylianos

AIMThis study aimed to assess the health profile of patient-attendees visiting primary healthcare (PHC) practice settings in the midst of the COVID-19 pandemic and to explore the relationships between multiple behavioral risk factors (MBRFs) and consultation-driven health information. Multiple behavioral risk factors involve a variety of unhealthy behaviors that are associated with an increased prevalence of non-communicable diseases (NCDs).SUBJECTS AND METHODSThe study design was based on a dataset analysis, afterward exploring the feasibility and diagnostic capacity of respiratory morbidity aspects from a study previously conducted. The study dataset contained information regarding socio-demographic characteristics, health habits, clinical information, and reported comorbidities from 183 primary care patient-attendees. A categorical regression analysis was performed, using as a numeric variable the multiple MBRFs (clustering of 0 to four factors) in order to examine relationships with the basic and clinical characteristics of the patient-attendees.RESULTSBased on this secondary analysis, it was found that the prevalence of MBRFs is quite common among patient-attendees visiting urban PHC facilities. The prevalence of current smoking, sleep deprivation, increased body weight, and medium/high perceived stress levels were 33.9%, 52.5%, 83.1%, and 35.0%, respectively. An increased occurrence of MBRFs might be significantly predicted by the lower age of patient-attendees (b = -0.221, p = 0.05), by the absence of gray hair at an early age (b = -0.144, p = 0.042), by the physical discomfort during activities (b = 0.191, p = 0.017), or by the lower oxygen saturation (b = -0.184, p = 0.004). Diabetes mellitus (25.1%) was the most prevalent condition, followed by bronchial asthma (18.6%) and depression (15.8%).CONCLUSIONSLower age, absence of premature hair whitening, physical discomfort during activities, and lower oxygen saturation are linked with an increased occurrence of MBRFs, leading to a neglected way of living. Those factors could be used to alert researchers, policymakers, and PHC professionals to act accordingly in order to prevent or early diagnose NCDs.

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