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更新于：2025-05-07

Tibial Meniscus Injuries

胫骨半月板损伤

更新于：2025-05-07

基本信息

别名

Injuries, Tibial Meniscus、Injury, Tibial Meniscus、Meniscus Injuries, Tibial

+ [4]

简介

Injuries to the TIBIAL MENISCUS of the leg.

关联

靶点-

作用机制-

在研机构

Eskisehir Osmangazi üniversitesi

原研机构

Eskisehir Osmangazi üniversitesi

在研适应症

关节痛 [+5]

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

Synovial fluid mesenchymal stem cell-derived exosome(Eskisehir Osmangazi University)

靶点-

作用机制-

在研机构

Eskisehir Osmangazi üniversitesi

原研机构

Eskisehir Osmangazi üniversitesi

在研适应症

关节痛 [+5]

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与胫骨半月板损伤相关的临床试验

NCT05505747

/ Not yet recruiting临床2/3期IIT

Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair

Arthroscopic meniscal procedures are the most commonly performed orthopaedic procedure in the U.S. affecting 15% of Americans ages 10-65 years. Meniscus injury is also known to increase the risk of posttraumatic osteoarthritis (PTOA). The current randomized clinical trial will test a novel intervention after meniscal repair that combines an oral senolytic fisetin and real-time biofeedback program to restore joint loading and subsequent return to activity.

开始日期2025-07-01

申办/合作机构

University of Kentucky

ACTRN12625000040460

/ Not yet recruitingN/A

Changes in Hair Density of the Free Flap Following Preoperative Laser Depilation of Donor Site in Head and Neck Cancer Free Flap Reconstruction [LaDDoR]

开始日期2025-02-03

申办/合作机构

Chris O'Brien Lifehouse

NCT06376422

/ RecruitingN/AIIT

Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss, an Investigator-initiated Low Interventional Trial.

The goal of this clinical trial is to learn if partial meniscal replacement can prevent or postpone total meniscal replacement, in adult patients (female/male) with partial meniscal loss. The main questions it aims to answer are:
Can partial meniscal replacement improve knee function?
Can partial meniscal replacement prevent/postpone total meniscal replacement/knee prothesis? Researchers will compare the results of the operated group with patients not willing to be operated but with partial meniscal loss to see if the operation improves knee function.
Participants will be operated and have to attend follow-up visits with MRI after 6 months up to 5 years after surgery.

开始日期2024-05-01

申办/合作机构-

100 项与胫骨半月板损伤相关的临床结果

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100 项与胫骨半月板损伤相关的转化医学

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0 项与胫骨半月板损伤相关的专利（医药）

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261

项与胫骨半月板损伤相关的文献（医药）

2025-08-01·The Knee

Bicruciate knee ligament deficiency is less harmful to the meniscus and chondral tissue than isolated cruciate injuries

Article

作者: Piedade, Sérgio Rocha ; Ferreira, Daniel Miranda ; Maffulli, Nicola

OBJECTIVESimultaneous injury to both cruciate ligaments seriously compromises the kinematics of the knee joint. This study aims to retrospectively investigate the incidence of meniscus and chondral injuries and extra-articular injuries in a series of 25 consecutive patients with chronic bicruciate knee ligament injuries managed surgically.MATERIAL AND METHODSThe patient's mean age was 27.7 ± 5.1, median 28.00 (17.00-37.00), and 80% were male (n = 20). The average injury time to surgery was 12 months (1-96 months). Recorded data on intra- and extra-articular knee injuries were compared between genders, according to age, meniscal and chondral injuries, and mechanism of trauma in 25 patients with bicruciate knee ligament injury. Knee magnetic resonance imaging (MRI) exams were collected and examined.RESULTSMeniscal injuries occurred in 40% of patients, with intra-substance signal alteration (grade I and II), meniscocapsular injury or small extension of the injury to the articular surface of the meniscus. No complex meniscal injury or displaced meniscal fragments were observed at MRI and at surgery, with minor chondral injuries or bone bruises.CONCLUSIONBicruciate knee ligament deficiency is less harmful to the meniscus and chondral tissue than isolated anterior cruciate ligament (ACL) tears, suggesting that this injury pattern leads to lower abnormal compression and shear forces on the joint surfaces. It could indicate that the "compass right-arm injury" of the femoral condyle on tibial components (meniscus and chondral tissue) is heightened in isolated cruciate knee ligament injuries, resulting in more complex damage than in bicruciate ligament tears. Given the high-energy trauma involved, extra-articular injuries could take place, and they should be taken into account in surgical decision-making.LEVEL OF EVIDENCE IVCase series.

2025-03-01·ANZ Journal of Surgery

Increase in paediatric bone stress injuries: a single‐center study during the COVID‐19 pandemic

Article

作者: Donnan, Leo ; Morrison, Stewart ; Browne, Robert ; Behman, Amy

AbstractBackgroundMelbourne, Australia was considered the most locked‐down city during the COVID19 Pandemic. School was conducted from home and all organized sport ceased. Our institution noted an increased presentation of bone stress injuries (BSI) ranging from periostitis to stress fractures. This study reviews the prevalence of these injuries to gain insights into BSI presentation, diagnosis and best management.MethodsA retrospective review of lower limb long bone stress injuries between April 1st 2020 and March 31st 2022, and from 2018 to 2020 for comparison, was conducted. A chart review of those meeting inclusion criteria for demographics, fracture characteristics, investigations, and treatment administered was conducted.ResultsThirteen patients (two female, 11 male) met inclusion criteria. Only four patients were identified in the comparison period. The average age was 11.6 years, and average symptom duration was 7 weeks. Distinct morphologies were noted, specifically three discrete patterns of tibial injury were identified. Patients underwent an average of three imaging studies prior to diagnosis. Nine of 13 patients were prescribed a period of non‐weight bearing, averaging 3.5 weeks. Seven of 13 patients were prescribed a formal ‘partial weight bearing’ (50%) period averaging 6.4 weeks.ConclusionThere was a significant increase in paediatric BSI presentation over the COVID‐19 lockdowns. This may be linked to the effect of reduced physical activity. Knowledge of the three clear tibial morphologies identified in this study will inform future diagnosis and reduce investigation expenditure. These findings may inform public health measures during mandated lockdowns and raise a diagnostic framework for such injuries.

2025-03-01·Journal of Orthopaedic Science

Subchondral insufficiency fractures of the medial tibial condyle are associated with medial meniscus extrusion: A retrospective observational study

Article

作者: Onuma, Hiroyuki ; Uehara, Kenji ; Niki, Hisateru ; Ono, Mahiro ; Kotani, Takashi ; Minakawa, Naoki ; Kumai, Takanori ; Akazawa, Tsutomu ; Kishiro, Satoshi ; Kudo, Takaaki

BACKGROUNDTo the best of our knowledge, no prior studies have identified any risk factors for subchondral insufficiency fractures of the medial tibial condyle. This study aimed to explain relationships between subchondral insufficiency fractures of the medial tibial condyle and the meniscus status, lower extremity alignment, or osteoporosis.METHODSThis retrospective study included 325 consecutive patients whose chief complaint is knee joint pain and who had visited one institution between April 2016 and March 2021, of which 70 patients (8 men and 62 women) who had suspected subchondral insufficiency fractures of the medial tibial condyle had undergone magnetic resonance imaging and radiographic examination. These patients were divided into two groups based on the results of their magnetic resonance imaging: the insufficiency fracture group included 46 patients who had subchondral insufficiency fractures of the medial tibial condyle and the nonfracture group included 24 patients without fractures. The meniscus injury and medial meniscus extrusion (MME) were evaluated by using magnetic resonance imaging. The Kellgren-Lawrence grade, the femorotibial angle, and the percent mechanical axis (%MA) were evaluated with the use of knee radiographs. T-scores were also measured by using dual-energy X-ray absorptiometry with a bone densitometer.RESULTSMME were significantly larger and the %MA was significantly smaller in the insufficiency fracture group than that in the nonfracture group. The prevalence of medial meniscus injuries and pathological MME were higher in the insufficiency fracture group than those in the nonfracture group. The prevalence of varus knee and osteoporosis did not vary remarkably different between the two groups.CONCLUSIONThe patients who had insufficiency fractures of the medial tibial condyle tended to have medial meniscus extrusion.

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